Tag | Content |
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CPLM ID | CPLM-019818 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | BAG family molecular chaperone regulator 1 |
Protein Synonyms/Alias | BAG-1; Bcl-2-associated athanogene 1 |
Gene Name | BAG1 |
Gene Synonyms/Alias | HAP |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
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202 | LQAEALCKLDRRVKA | ubiquitination | [1] |
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Reference | [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties. Chen Z, Zhou Y, Song J, Zhang Z. Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [ PMID: 23603789] |
Functional Description | Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli. |
Sequence Annotation | REPEAT 96 101 1. REPEAT 102 107 2. REPEAT 108 113 3. REPEAT 114 119 4. REPEAT 120 125 5. REPEAT 126 131 6. REPEAT 132 137 7. DOMAIN 144 224 Ubiquitin-like. DOMAIN 246 326 BAG. REGION 96 137 7 X 6 AA tandem repeat of E-E-X(4). REGION 172 219 Interaction with HSPA8. REGION 216 345 Interaction with PPP1R15A. MOD_RES 223 223 Phosphoserine. |
Keyword | 3D-structure; Alternative initiation; Alternative splicing; Apoptosis; Chaperone; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Repeat; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 345 AA |
Protein Sequence | MKKKTRRRST RSEELTRSEE LTLSEEATWS EEATQSEEAT QGEEMNRSQE VTRDEESTRS 60 EEVTREEMAA AGLTVTVTHS NEKHDLHVTS QQGSSEPVVQ DLAQVVEEVI GVPQSFQKLI 120 FKGKSLKEME TPLSALGIQD GCRVMLIGKK NSPQEEVELK KLKHLEKSVE KIADQLEELN 180 KELTGIQQGF LPKDLQAEAL CKLDRRVKAT IEQFMKILEE IDTLILPENF KDSRLKRKGL 240 VKKVQAFLAE CDTVEQNICQ ETERLQSTNF ALAE 274 |
Gene Ontology | GO:0005737; C:cytoplasm; TAS:ProtInc. GO:0005634; C:nucleus; IDA:UniProtKB. GO:0005057; F:receptor signaling protein activity; TAS:ProtInc. GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. GO:0007166; P:cell surface receptor signaling pathway; TAS:ProtInc. GO:0070389; P:chaperone cofactor-dependent protein refolding; IDA:UniProtKB. GO:0043066; P:negative regulation of apoptotic process; TAS:ProtInc. |
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