CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005735
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Anaerobic ribonucleoside-triphosphate reductase 
Protein Synonyms/Alias
  
Gene Name
 nrdD 
Gene Synonyms/Alias
 b4238; JW4197 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
138LLAGIVAKHYARQHLacetylation[1, 2]
329RKTAVFPKLVFAIRDacetylation[2]
429GDEATFWKLLDERLVacetylation[2]
481DDVSEIFKNGRASISacetylation[2]
Reference
 [1] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111]
 [2] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
  
Sequence Annotation
 DOMAIN 3 92 ATP-cone.
 DOMAIN 583 708 Glycine radical.
 METAL 644 644 Zinc.
 METAL 647 647 Zinc.
 METAL 662 662 Zinc.
 METAL 665 665 Zinc.
 MOD_RES 681 681 Glycine radical (By similarity).  
Keyword
 ATP-binding; Complete proteome; Direct protein sequencing; Metal-binding; Nucleotide-binding; Organic radical; Oxidoreductase; Reference proteome; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 712 AA 
Protein Sequence
MTPHVMKRDG CKVPFKSERI KEAILRAAKA AEVDDADYCA TVAAVVSEQM QGRNQVDINE 60
IQTAVENQLM SGPYKQLARA YIEYRHDRDI EREKRGRLNQ EIRGLVEQTN ASLLNENANK 120
DSKVIPTQRD LLAGIVAKHY ARQHLLPRDV VQAHERGDIH YHDLDYSPFF PMFNCMLIDL 180
KGMLTQGFKM GNAEIEPPKS ISTATAVTAQ IIAQVASHIY GGTTINRIDE VLAPFVTASY 240
NKHRKTAEEW NIPDAEGYAN SRTIKECYDA FQSLEYEVNT LHTANGQTPF VTFGFGLGTS 300
WESRLIQESI LRNRIAGLGK NRKTAVFPKL VFAIRDGLNH KKGDPNYDIK QLALECASKR 360
MYPDILNYDQ VVKVTGSFKT PMGCRSFLGV WENENGEQIH DGRNNLGVIS LNLPRIALEA 420
KGDEATFWKL LDERLVLARK ALMTRIARLE GVKARVAPIL YMEGACGVRL NADDDVSEIF 480
KNGRASISLG YIGIHETINA LFGGEHVYDN EQLRAKGIAI VERLRQAVDQ WKEETGYGFS 540
LYSTPSENLC DRFCRLDTAE FGVVPGVTDK GYYTNSFHLD VEKKVNPYDK IDFEAPYPPL 600
ANGGFICYGE YPNIQHNLKA LEDVWDYSYQ HVPYYGTNTP IDECYECGFT GEFECTSKGF 660
TCPKCGNHDA SRVSVTRRVC GYLGSPDARP FNAGKQEEVK RRVKHLGNGQ IG 712 
Gene Ontology
 GO:0031250; C:anaerobic ribonucleoside-triphosphate reductase complex; IMP:EcoliWiki.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0051065; F:CTP reductase activity; IDA:EcoCyc.
 GO:0008270; F:zinc ion binding; IDA:EcoCyc.
 GO:0006260; P:DNA replication; IEA:InterPro.
 GO:0015949; P:nucleobase-containing small molecule interconversion; IMP:EcoliWiki. 
Interpro
 IPR005144; ATP-cone.
 IPR019777; Form_AcTrfase_GR_CS.
 IPR001150; Gly_radical.
 IPR012833; NrdD. 
Pfam
 PF03477; ATP-cone 
SMART
  
PROSITE
 PS51161; ATP_CONE
 PS00850; GLY_RADICAL_1
 PS51149; GLY_RADICAL_2 
PRINTS