CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000108
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 U3 small nucleolar ribonucleoprotein protein MPP10 
Protein Synonyms/Alias
 M phase phosphoprotein 10 
Gene Name
 MPHOSPH10 
Gene Synonyms/Alias
 MPP10 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
51KVLYDFNKILENGRIubiquitination[1]
484YIKLNQQKTAEEENPubiquitination[2]
518SNFHFIPKPPVPEIKubiquitination[3]
609SSVDQAGKYSKTVASacetylation[4]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [4] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 
Functional Description
 Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing. 
Sequence Annotation
 MOD_RES 61 61 Phosphoserine (Potential).
 MOD_RES 120 120 Phosphoserine.
 MOD_RES 139 139 Phosphoserine.
 MOD_RES 163 163 Phosphoserine.
 MOD_RES 167 167 Phosphoserine.
 MOD_RES 171 171 Phosphoserine.
 MOD_RES 242 242 Phosphoserine.
 MOD_RES 275 275 Phosphoserine.
 MOD_RES 289 289 Phosphoserine.
 MOD_RES 609 609 N6-acetyllysine.  
Keyword
 Acetylation; Chromosome; Coiled coil; Complete proteome; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Ribonucleoprotein; Ribosome biogenesis; rRNA processing. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 681 AA 
Protein Sequence
MAPQVWRRRT LERCLTEVGK ATGRPECFLT IQEGLASKFT SLTKVLYDFN KILENGRIHG 60
SPLQKLVIEN FDDEQIWQQL ELQNEPILQY FQNAVSETIN DEDISLLPES EEQEREEDGS 120
EIEADDKEDL EDLEEEEVSD MGNDDPEMGE RAENSSKSDL RKSPVFSDED SDLDFDISKL 180
EQQSKVQNKG QGKPREKSIV DDKFFKLSEM EAYLENIEKE EERKDDNDEE EEDIDFFEDI 240
DSDEDEGGLF GSKKLKSGKS SRNLKYKDFF DPVESDEDIT NVHDDELDSN KEDDEIAEEE 300
AEELSISETD EDDDLQENED NKQHKESLKR VTFALPDDAE TEDTGVLNVK KNSDEVKSSF 360
EKRQEKMNEK IASLEKELLE KKPWQLQGEV TAQKRPENSL LEETLHFDHA VRMAPVITEE 420
TTLQLEDIIK QRIRDQAWDD VVRKEKPKED AYEYKKRLTL DHEKSKLSLA EIYEQEYIKL 480
NQQKTAEEEN PEHVEIQKMM DSLFLKLDAL SNFHFIPKPP VPEIKVVSNL PAITMEEVAP 540
VSVSDAALLA PEEIKEKNKA GDIKTAAEKT ATDKKRERRK KKYQKRMKIK EKEKRRKLLE 600
KSSVDQAGKY SKTVASEKLK QLTKTGKASF IKDEGKDKAL KSSQAFFSKL QDQVKMQIND 660
AKKTEKKKKK RQDISVHKLK L 681 
Gene Ontology
 GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
 GO:0005730; C:nucleolus; IDA:UniProtKB.
 GO:0005732; C:small nucleolar ribonucleoprotein complex; NAS:UniProtKB.
 GO:0010923; P:negative regulation of phosphatase activity; IDA:UniProtKB.
 GO:0000375; P:RNA splicing, via transesterification reactions; NAS:UniProtKB.
 GO:0006364; P:rRNA processing; IEA:UniProtKB-KW. 
Interpro
 IPR007151; Mpp10.
 IPR012173; snoRNP_Mpp10. 
Pfam
 PF04006; Mpp10 
SMART
  
PROSITE
  
PRINTS