Tag | Content |
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CPLM ID | CPLM-009144 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Tropomyosin beta chain |
Protein Synonyms/Alias | Beta-tropomyosin; Tropomyosin-2 |
Gene Name | Tpm2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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29 | AEQAEADKKQAEDRC | acetylation | [1] | 30 | EQAEADKKQAEDRCK | acetylation | [1] | 48 | EEQQALQKKLKGTED | acetylation | [1] | 49 | EQQALQKKLKGTEDE | acetylation | [1] | 51 | QALQKKLKGTEDEVE | acetylation | [1] | 59 | GTEDEVEKYSESVKD | acetylation | [1] | 65 | EKYSESVKDAQEKLE | acetylation | [1] | 70 | SVKDAQEKLEQAEKK | acetylation | [1] | 76 | EKLEQAEKKATDAEA | acetylation | [1] | 136 | VIENRAMKDEEKMEL | acetylation | [1] | 140 | RAMKDEEKMELQEMQ | acetylation | [1] | 149 | ELQEMQLKEAKHIAE | acetylation | [1] | 152 | EMQLKEAKHIAEDSD | acetylation | [1] | 168 | KYEEVARKLVILEGE | acetylation | [1] | 198 | GDLEEELKIVTNNLK | acetylation | [1] | 205 | KIVTNNLKSLEAQAD | acetylation | [1] | 213 | SLEAQADKYSTKEDK | acetylation | [1] | 217 | QADKYSTKEDKYEEE | acetylation | [1] | 220 | KYSTKEDKYEEEIKL | acetylation | [1] | 226 | DKYEEEIKLLEEKLK | acetylation | [1] | 248 | FAERSVAKLEKTIDD | acetylation | [1] | 251 | RSVAKLEKTIDDLED | acetylation | [1] | 264 | EDEVYAQKMKYKAIS | acetylation | [1] | 268 | YAQKMKYKAISEELD | acetylation | [1] |
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Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization (By similarity). |
Sequence Annotation | MOD_RES 1 1 N-acetylmethionine (By similarity). MOD_RES 61 61 Phosphoserine; by PIK3CG (By similarity). MOD_RES 252 252 Phosphothreonine (By similarity). MOD_RES 283 283 Phosphoserine (By similarity). |
Keyword | Acetylation; Actin-binding; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Muscle protein; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 284 AA |
Protein Sequence | MDAIKKKMQM LKLDKENAID RAEQAEADKK QAEDRCKQLE EEQQALQKKL KGTEDEVEKY 60 SESVKDAQEK LEQAEKKATD AEADVASLNR RIQLVEEELD RAQERLATAL QKLEEAEKAA 120 DESERGMKVI ENRAMKDEEK MELQEMQLKE AKHIAEDSDR KYEEVARKLV ILEGELERSE 180 ERAEVAESKC GDLEEELKIV TNNLKSLEAQ ADKYSTKEDK YEEEIKLLEE KLKEAETRAE 240 FAERSVAKLE KTIDDLEDEV YAQKMKYKAI SEELDNALND ITSL 284 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |