CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037171
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Squalene monooxygenase 
Protein Synonyms/Alias
  
Gene Name
 SQLE 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
173MGVQYKDKETGDIKEubiquitination[1]
195VADGLFSKFRKSLVSubiquitination[1, 2, 3]
223MKNAPQFKANHAELIubiquitination[1]
268LREYMVEKIYPQIPDubiquitination[1]
278PQIPDHLKEPFLEATubiquitination[1]
331GGMTVAFKDIKLWRKubiquitination[1, 2]
338KDIKLWRKLLKGIPDubiquitination[1]
341KLWRKLLKGIPDLYDubiquitination[1, 4, 5]
356DAAIFEAKKSFYWARubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 479 AA 
Protein Sequence
MLRRKGTNIS ETSLIGTAAC TSTSSQNDPE VIIVGAGVLG SALAAVLSRD GRKVTVIERD 60
LKEPDRIVGE FLQPGGYHVL KDLGLGDTVE GLDAQVVNGY MIHDQESKSE VQIPYPLSEN 120
NQVQSGRAFH HGRFIMSLRK AAMAEPNAKF IEGVVLQLLE EDDVVMGVQY KDKETGDIKE 180
LHAPLTVVAD GLFSKFRKSL VSNKVSVSSH FVGFLMKNAP QFKANHAELI LANPSPVLIY 240
QISSSETRVL VDIRGEMPRN LREYMVEKIY PQIPDHLKEP FLEATDNSHL RSMPASFLPP 300
SSVKKRGVLL LGDAYNMRHP LTGGGMTVAF KDIKLWRKLL KGIPDLYDDA AIFEAKKSFY 360
WARKTSHSFV VNILAQALYE LFSATDDSLH QLRKACFLYF KLGGECVAGP VGLLSVLSPN 420
PLVLIGHFFA VAIYAVYFCF KSEPWITKPR ALLSSGAVLY KACSVIFPLI YSEMKYMVH 479 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:InterPro.
 GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
 GO:0004506; F:squalene monooxygenase activity; IEA:InterPro. 
Interpro
 IPR001327; Pyr_OxRdtase_NAD-bd_dom.
 IPR003042; Rng_hydrolase-like.
 IPR013698; Squalene_epoxidase. 
Pfam
 PF00070; Pyr_redox
 PF08491; SE 
SMART
  
PROSITE
  
PRINTS
 PR00420; RNGMNOXGNASE.