CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023118
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Histone deacetylase 9 
Protein Synonyms/Alias
 HD9; Histone deacetylase 7B; HD7; HD7b; Histone deacetylase-related protein; MEF2-interacting transcription repressor MITR 
Gene Name
 HDAC9 
Gene Synonyms/Alias
 HDAC7; HDAC7B; HDRP; KIAA0744; MITR 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
44VDPVVREKQLQQELLubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription. 
Sequence Annotation
 REGION 23 27 Interaction with CTBP1 (By similarity).
 REGION 136 154 Interaction with MEF2 (By similarity).
 REGION 175 343 Interaction with MAPK10 (By similarity).
 REGION 218 261 Interaction with ETV6.
 REGION 631 978 Histone deacetylase.
 ACT_SITE 783 783 By similarity.
 METAL 646 646 Zinc (By similarity).
 METAL 648 648 Zinc (By similarity).
 METAL 654 654 Zinc (By similarity).
 METAL 731 731 Zinc (By similarity).
 MOD_RES 22 22 Phosphoserine.
 MOD_RES 220 220 Phosphoserine (By similarity).
 MOD_RES 240 240 Phosphoserine (By similarity).
 MOD_RES 451 451 Phosphoserine (By similarity).  
Keyword
 Alternative splicing; Chromatin regulator; Chromosomal rearrangement; Complete proteome; Hydrolase; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repressor; Transcription; Transcription regulation; Ubl conjugation; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1011 AA 
Protein Sequence
MHSMISSVDV KSEVPVGLEP ISPLDLRTDL RMMMPVVDPV VREKQLQQEL LLIQQQQQIQ 60
KQLLIAEFQK QHENLTRQHQ AQLQEHIKEL LAIKQQQELL EKEQKLEQQR QEQEVERHRR 120
EQQLPPLRGK DRGRERAVAS TEVKQKLQEF LLSKSATKDT PTNGKNHSVS RHPKLWYTAA 180
HHTSLDQSSP PLSGTSPSYK YTLPGAQDAK DDFPLRKTAS EPNLKVRSRL KQKVAERRSS 240
PLLRRKDGNV VTSFKKRMFE VTESSVSSSS PGSGPSSPNN GPTGSVTENE TSVLPPTPHA 300
EQMVSQQRIL IHEDSMNLLS LYTSPSLPNI TLGLPAVPSQ LNASNSLKEK QKCETQTLRQ 360
GVPLPGQYGG SIPASSSHPH VTLEGKPPNS SHQALLQHLL LKEQMRQQKL LVAGGVPLHP 420
QSPLATKERI SPGIRGTHKL PRHRPLNRTQ SAPLPQSTLA QLVIQQQHQQ FLEKQKQYQQ 480
QIHMNKLLSK SIEQLKQPGS HLEEAEEELQ GDQAMQEDRA PSSGNSTRSD SSACVDDTLG 540
QVGAVKVKEE PVDSDEDAQI QEMESGEQAA FMQQPFLEPT HTRALSVRQA PLAAVGMDGL 600
EKHRLVSRTH SSPAASVLPH PAMDRPLQPG SATGIAYDPL MLKHQCVCGN STTHPEHAGR 660
IQSIWSRLQE TGLLNKCERI QGRKASLEEI QLVHSEHHSL LYGTNPLDGQ KLDPRILLGD 720
DSQKFFSSLP CGGLGVDSDT IWNELHSSGA ARMAVGCVIE LASKVASGEL KNGFAVVRPP 780
GHHAEESTAM GFCFFNSVAI TAKYLRDQLN ISKILIVDLD VHHGNGTQQA FYADPSILYI 840
SLHRYDEGNF FPGSGAPNEV GTGLGEGYNI NIAWTGGLDP PMGDVEYLEA FRTIVKPVAK 900
EFDPDMVLVS AGFDALEGHT PPLGGYKVTA KCFGHLTKQL MTLADGRVVL ALEGGHDLTA 960
ICDASEACVN ALLGNELEPL AEDILHQSPN MNAVISLQKI IEIQSMSLKF S 1011 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0000118; C:histone deacetylase complex; TAS:UniProtKB.
 GO:0035097; C:histone methyltransferase complex; ISS:UniProtKB.
 GO:0005667; C:transcription factor complex; IDA:BHF-UCL.
 GO:0004407; F:histone deacetylase activity; IDA:BHF-UCL.
 GO:0042826; F:histone deacetylase binding; IDA:BHF-UCL.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.
 GO:0097372; F:NAD-dependent histone deacetylase activity (H3-K18 specific); IEA:EC.
 GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.
 GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.
 GO:0070491; F:repressing transcription factor binding; IDA:BHF-UCL.
 GO:0003714; F:transcription corepressor activity; ISS:BHF-UCL.
 GO:0030183; P:B cell differentiation; TAS:UniProtKB.
 GO:0032869; P:cellular response to insulin stimulus; IDA:BHF-UCL.
 GO:0007507; P:heart development; ISS:BHF-UCL.
 GO:0070932; P:histone H3 deacetylation; IDA:BHF-UCL.
 GO:0070933; P:histone H4 deacetylation; IDA:BHF-UCL.
 GO:0006954; P:inflammatory response; TAS:UniProtKB.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:BHF-UCL.
 GO:0007219; P:Notch signaling pathway; TAS:Reactome.
 GO:0034983; P:peptidyl-lysine deacetylation; IDA:BHF-UCL.
 GO:0090050; P:positive regulation of cell migration involved in sprouting angiogenesis; IMP:BHF-UCL.
 GO:0048742; P:regulation of skeletal muscle fiber development; ISS:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR000286; His_deacetylse.
 IPR023801; His_deacetylse_dom.
 IPR024643; Hist_deacetylase_Gln_rich_N.
 IPR017320; Histone_deAcase_II_euk. 
Pfam
 PF12203; HDAC4_Gln
 PF00850; Hist_deacetyl 
SMART
  
PROSITE
  
PRINTS
 PR01270; HDASUPER.