UniProt Accession

 JOS1_MOUSE; Q9DBJ6; Q3U3E9 

Genbank Protein ID

 AK004913; AK154799; BC006928; BC086769 

Genbank Nucleotide ID

 BAB23664.1; BAE32837.1; AAH06928.1; AAH86769.1 

Protein Name

 Josephin-1 

Protein Synonyms/Alias

 Josephin domain-containing protein 1 

Gene Name

 Josd1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
74	TMVTPHKKSMLGNGN	ubiquitination	[1]
180	LKYHLRGKNCELLLV	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Has low protease activity towards poly-ubiquitin chains (in vitro). May act as a deubiquitinating enzyme (By similarity). 

Sequence Annotation

 DOMAIN 23 202 Josephin.
 ACT_SITE 36 36 Nucleophile (By similarity).
 ACT_SITE 139 139 Proton acceptor (By similarity).  

Keyword

 Complete proteome; Hydrolase; Protease; Reference proteome; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 202 AA 

Protein Sequence

Gene Ontology

 GO:0008242; F:omega peptidase activity; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 

Interpro

 IPR006155; Josephin. 

Pfam

 PF02099; Josephin 

SMART

  

PROSITE

 PS50957; JOSEPHIN 

PRINTS