CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033890
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Prelamin-A/C 
Protein Synonyms/Alias
  
Gene Name
 Lmna 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
32RITRLQEKEDLQELNacetylation[1, 2, 3]
32RITRLQEKEDLQELNsuccinylation[3]
32RITRLQEKEDLQELNubiquitination[4]
78SREVSGIKAAYEAELubiquitination[4]
90AELGDARKTLDSVAKacetylation[3]
90AELGDARKTLDSVAKsuccinylation[3]
97KTLDSVAKERARLQLubiquitination[4]
108RLQLELSKVREEFKEacetylation[1, 2, 3]
108RLQLELSKVREEFKEubiquitination[4]
114SKVREEFKELK****acetylation[2]
114SKVREEFKELK****ubiquitination[4]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Intermediate filament; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 117 AA 
Protein Sequence
METPSQRRAT RSGAQASSTP LSPTRITRLQ EKEDLQELND RLAVYIDRVR SLETENAGLR 60
LRITESEEVV SREVSGIKAA YEAELGDARK TLDSVAKERA RLQLELSKVR EEFKELK 117 
Gene Ontology
 GO:0005638; C:lamin filament; IDA:MGI.
 GO:0005635; C:nuclear envelope; IDA:MGI.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0005198; F:structural molecule activity; IEA:InterPro.
 GO:0071456; P:cellular response to hypoxia; IEA:Compara.
 GO:0007517; P:muscle organ development; IEA:Compara.
 GO:0006998; P:nuclear envelope organization; IGI:MGI.
 GO:0090343; P:positive regulation of cell aging; IEA:Compara.
 GO:0035105; P:sterol regulatory element binding protein import into nucleus; IMP:MGI.
 GO:0055015; P:ventricular cardiac muscle cell development; IMP:MGI. 
Interpro
 IPR016044; F.
 IPR001664; IF. 
Pfam
 PF00038; Filament 
SMART
  
PROSITE
  
PRINTS