UniProt Accession

 ATG10_HUMAN; Q9H0Y0; B2RE09; Q6PIX1; Q9H842 

Genbank Protein ID

 AF318326; AK024016; AK315752; AL136912; BC004551; BC027718; BC029268 

Genbank Nucleotide ID

 AAL55833.1; BAB14778.1; BAG38106.1; CAB66846.1; AAH29268.1 

Protein Name

 Ubiquitin-like-conjugating enzyme ATG10 

Protein Synonyms/Alias

 Autophagy-related protein 10; APG10-like 

Gene Name

 ATG10 

Gene Synonyms/Alias

 APG10L; PP12616 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
10	EDEFIGEKTFQRYCA	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5-recognition molecule. Not involved in ATG12 conjugation to ATG3 (By similarity). Plays a role in adenovirus-mediated cell lysis. 

Sequence Annotation

  

Keyword

 Alternative splicing; Autophagy; Complete proteome; Cytoplasm; Ligase; Polymorphism; Protein transport; Reference proteome; Transport; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 220 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005622; C:intracellular; IDA:LIFEdb.
 GO:0019777; F:Atg12 ligase activity; ISS:UniProtKB.
 GO:0034263; P:autophagy in response to ER overload; IMP:UniProtKB.
 GO:0031401; P:positive regulation of protein modification process; ISS:UniProtKB.
 GO:0006497; P:protein lipidation; ISS:UniProtKB.
 GO:0032446; P:protein modification by small protein conjugation; IDA:UniProtKB.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 

Interpro

 IPR007135; Autophagy-rel_prot_3. 

Pfam

 PF03987; Autophagy_act_C 

SMART

  

PROSITE

  

PRINTS