UniProt Accession

 ACEA_ECOLI; P0A9G6; P05313; Q2M6T9 

Genbank Protein ID

 X12431; X07543; M22621; U00006; U00096; AP009048; M20714 

Genbank Nucleotide ID

 CAA30974.1; CAA30416.1; AAC13650.1; AAC43109.1; AAC76985.1; BAE78017.1; AAA24009.1 

Protein Name

 Isocitrate lyase 

Protein Synonyms/Alias

 ICL; Isocitrase; Isocitratase 

Gene Name

 aceA 

Gene Synonyms/Alias

 icl; b4015; JW3975 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
13	QQIEELQKEWTQPRW	acetylation	[1, 2]
34	YSAEDVVKLRGSVNP	acetylation	[1, 2]
52	LAQLGAAKMWRLLHG	acetylation	[1]
62	RLLHGESKKGYINSL	acetylation	[1]
193	EDQLASVKKCGHMGG	acetylation	[1, 2]
194	DQLASVKKCGHMGGK	acetylation	[1]
201	KCGHMGGKVLVPTQE	acetylation	[1, 2]
212	PTQEAIQKLVAARLA	acetylation	[1, 3]
308	FAQAIHAKYPGKLLA	acetylation	[1, 2]
312	IHAKYPGKLLAYNCS	acetylation	[1]
326	SPSFNWQKNLDDKTI	acetylation	[1, 2]
331	WQKNLDDKTIASFQQ	acetylation	[1, 2]
381	GMKHYVEKVQQPEFA	acetylation	[1, 2]
391	QPEFAAAKDGYTFVS	acetylation	[1, 2]

Reference

 [1] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111]
 [2] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618]
 [3] The diversity of lysine-acetylated proteins in Escherichia coli.
 Yu BJ, Kim JA, Moon JH, Ryu SE, Pan JG.
 J Microbiol Biotechnol. 2008 Sep;18(9):1529-36. [PMID: 18852508] 

Functional Description

 Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway (By similarity). 

Sequence Annotation

 ACT_SITE 195 195 Probable.  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Glyoxylate bypass; Lyase; Phosphoprotein; Reference proteome; Tricarboxylic acid cycle. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 434 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0043169; F:cation binding; IDA:EcoliWiki.
 GO:0004451; F:isocitrate lyase activity; IDA:EcoliWiki.
 GO:0006097; P:glyoxylate cycle; IC:EcoliWiki.
 GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW. 

Interpro

 IPR006254; Isocitrate_lyase.
 IPR000918; Isocitrate_lyase/Pmutase.
 IPR018523; Isocitrate_lyase_ph_CS.
 IPR015813; Pyrv/PenolPyrv_Kinase-like_dom. 

Pfam

 PF00463; ICL 

SMART

  

PROSITE

 PS00161; ISOCITRATE_LYASE 

PRINTS