CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031277
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Bifunctional apoptosis regulator 
Protein Synonyms/Alias
 cDNA FLJ58979, highly similar to Bifunctional apoptosis regulator 
Gene Name
 BFAR 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
97LTEEEFSKTPYTIENubiquitination[1, 2, 3, 4, 5]
119LMELERVKALGVKPPubiquitination[1]
124RVKALGVKPPQNLWEubiquitination[1, 4, 5]
133PQNLWEYKAVNPGRSubiquitination[1, 4]
194VTKLLDLKEPTWKQWubiquitination[1, 2, 3]
199DLKEPTWKQWREFLVubiquitination[1]
259IWSRSELKTVPQRMWubiquitination[2, 5, 6]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [6] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 322 AA 
Protein Sequence
MVGIFKENRM SRMQRKMGRF PQSQYSPQVV LLVYHWSSRE SEHDLLVHKA VAKWTAEEVV 60
LWLEQLGPWA SLYRERFLSE RVNGRLLLTL TEEEFSKTPY TIENSSHRRA ILMELERVKA 120
LGVKPPQNLW EYKAVNPGRS LFLLYALKSS PRLSLLYLYL FDYTDTFLPF IHTICPLQED 180
SSGEDIVTKL LDLKEPTWKQ WREFLVKYSF LPYQLIAEFA WDWLEVHYWT SRFLIINAML 240
LSVLELFSFW RIWSRSELKT VPQRMWSHFW KVSTQGLFVA MFWPLIPQFV CNCLFYWALY 300
FNPIINIDLV VKELRRLETQ VL 322 
Gene Ontology
  
Interpro
 IPR001660; SAM.
 IPR013761; SAM/pointed.
 IPR021129; SAM_type1. 
Pfam
 PF00536; SAM_1 
SMART
 SM00454; SAM 
PROSITE
 PS50105; SAM_DOMAIN 
PRINTS