UniProt Accession

 LYPA1_MOUSE; P97823; Q3TJZ0; Q7TPX1; Q8BWM6 

Genbank Protein ID

 U89352; AK002674; AK050549; AK146874; AK167231; BC013536; BC052848 

Genbank Nucleotide ID

 AAB48627.1; BAB22276.1; BAC34318.1; BAE27497.1; BAE39355.1; AAH13536.1; AAH52848.1 

Protein Name

 Acyl-protein thioesterase 1 

Protein Synonyms/Alias

 APT-1; Lysophospholipase 1; Lysophospholipase I; LPL-I; LysoPLA I 

Gene Name

 Lypla1 

Gene Synonyms/Alias

 Apt1; Pla1a 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
97	KQAAETVKALIDQEV	acetylation	[1]
105	ALIDQEVKNGIPSNR	ubiquitination	[2]
190	SLTVERLKALINPAN	ubiquitination	[2]
224	DVKHFIDKLLPPID*	acetylation	[1]
224	DVKHFIDKLLPPID*	ubiquitination	[2]

Reference

 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity and also low lysophospholipase activity (By similarity). 

Sequence Annotation

 ACT_SITE 119 119 Charge relay system.
 ACT_SITE 174 174 Charge relay system.
 ACT_SITE 208 208 Charge relay system.  

Keyword

 Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Fatty acid metabolism; Hydrolase; Lipid metabolism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 230 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:MGI.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0008474; F:palmitoyl-(protein) hydrolase activity; ISS:UniProtKB.
 GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-KW.
 GO:0042997; P:negative regulation of Golgi to plasma membrane protein transport; IMP:MGI.
 GO:0002084; P:protein depalmitoylation; IMP:MGI. 

Interpro

 IPR003140; PLipase/COase/thioEstase. 

Pfam

 PF02230; Abhydrolase_2 

SMART

  

PROSITE

  

PRINTS