UniProt Accession

 MOES_MOUSE; P26041; B1AX70; Q3UL28; Q8BSN4 

Genbank Protein ID

 S47577; AK031171; AK088336; AK133819; AK145746; AK150869; AK153210; AL805963; BC047366; M86390 

Genbank Nucleotide ID

 AAA11762.1; BAC27288.1; BAC40290.1; BAE21861.1; BAE26623.1; BAE29920.1; BAE31809.1; CAM27501.1; AAH47366.1; AAA39728.1 

Protein Name

 Moesin 

Protein Synonyms/Alias

 Membrane-organizing extension spike protein 

Gene Name

 Msn 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
60	KAFSTWLKLNKKVTA	acetylation	[1]
60	KAFSTWLKLNKKVTA	ubiquitination	[2]
63	STWLKLNKKVTAQDV	acetylation	[1]
64	TWLKLNKKVTAQDVR	acetylation	[3]
64	TWLKLNKKVTAQDVR	succinylation	[3]
72	VTAQDVRKESPLLFK	acetylation	[1, 3]
72	VTAQDVRKESPLLFK	succinylation	[3]
72	VTAQDVRKESPLLFK	ubiquitination	[2]
79	KESPLLFKFRAKFYP	acetylation	[1, 3, 4]
79	KESPLLFKFRAKFYP	succinylation	[3]
79	KESPLLFKFRAKFYP	ubiquitination	[2]
83	LLFKFRAKFYPEDVS	ubiquitination	[2]
139	SKYGDFNKEVHKSGY	acetylation	[1]
139	SKYGDFNKEVHKSGY	ubiquitination	[2]
143	DFNKEVHKSGYLAGD	ubiquitination	[2]
151	SGYLAGDKLLPQRVL	acetylation	[3, 4]
151	SGYLAGDKLLPQRVL	succinylation	[3]
162	QRVLEQHKLNKDQWE	acetylation	[3]
162	QRVLEQHKLNKDQWE	ubiquitination	[2]
165	LEQHKLNKDQWEERI	acetylation	[1, 3]
165	LEQHKLNKDQWEERI	ubiquitination	[2]
209	GVNYFSIKNKKGSEL	ubiquitination	[2]
350	EKEELMEKLKQIEEQ	ubiquitination	[2]
352	EELMEKLKQIEEQTK	ubiquitination	[2]
360	QIEEQTKKAQQELEE	ubiquitination	[2]
400	RQEAEEAKEALLQAS	acetylation	[4]
412	QASRDQKKTQEQLAS	acetylation	[3]
438	LEMARKKKESEAVEW	acetylation	[1]
448	EAVEWQQKAQMVQED	ubiquitination	[2]
458	MVQEDLEKTRAELKT	acetylation	[1]
458	MVQEDLEKTRAELKT	ubiquitination	[2]
464	EKTRAELKTAMSTPH	ubiquitination	[2]
523	ERVQKHLKALTSELA	ubiquitination	[2]
537	ANARDESKKTANDMI	ubiquitination	[2]
538	NARDESKKTANDMIH	ubiquitination	[2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 Probably involved in connections of major cytoskeletal structures to the plasma membrane. 

Sequence Annotation

 DOMAIN 2 295 FERM.
 MOD_RES 79 79 N6-acetyllysine (By similarity).
 MOD_RES 116 116 Phosphotyrosine.
 MOD_RES 139 139 N6-acetyllysine (By similarity).
 MOD_RES 558 558 Phosphothreonine; by ROCK2 and STK10.
 MOD_RES 576 576 Phosphoserine.  

Keyword

 Acetylation; Cell membrane; Cell projection; Complete proteome; Cytoplasm; Cytoskeleton; Membrane; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 577 AA 

Protein Sequence

Gene Ontology

 GO:0016324; C:apical plasma membrane; IDA:MGI.
 GO:0016323; C:basolateral plasma membrane; IDA:MGI.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0070062; C:extracellular vesicular exosome; IEA:Compara.
 GO:0019898; C:extrinsic to membrane; IEA:InterPro.
 GO:0030175; C:filopodium; IEA:Compara.
 GO:0005925; C:focal adhesion; IEA:Compara.
 GO:0031528; C:microvillus membrane; IEA:UniProtKB-SubCell.
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0001931; C:uropod; IDA:MGI.
 GO:0007159; P:leukocyte cell-cell adhesion; IEA:Compara.
 GO:0050900; P:leukocyte migration; IEA:Compara.
 GO:0022614; P:membrane to membrane docking; IEA:Compara.
 GO:2000401; P:regulation of lymphocyte migration; IEA:Compara. 

Interpro

 IPR019749; Band_41_domain.
 IPR019750; Band_41_fam.
 IPR011174; ERM.
 IPR011259; ERM_C_dom.
 IPR000798; Ez/rad/moesin_like.
 IPR014352; FERM/acyl-CoA-bd_prot_3-hlx.
 IPR019748; FERM_central.
 IPR019747; FERM_CS.
 IPR000299; FERM_domain.
 IPR018979; FERM_N.
 IPR018980; FERM_PH-like_C.
 IPR008954; Moesin.
 IPR011993; PH_like_dom. 

Pfam

 PF00769; ERM
 PF09380; FERM_C
 PF00373; FERM_M
 PF09379; FERM_N 

SMART

 SM00295; B41 

PROSITE

 PS00660; FERM_1
 PS00661; FERM_2
 PS50057; FERM_3 

PRINTS

 PR00935; BAND41.
 PR00661; ERMFAMILY.