CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-035420
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Elongation factor 1-alpha 
Protein Synonyms/Alias
  
Gene Name
  
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
164TEPPYSQKRYEEIVKubiquitination[1]
430TVAVGVIKAVDKKAVacetylation[2]
430TVAVGVIKAVDKKAVubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity). 
Sequence Annotation
  
Keyword
 Complete proteome; Elongation factor; GTP-binding; Nucleotide-binding; Protein biosynthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 453 AA 
Protein Sequence
MGNEKTHISI VVIGHIDSGK STTTGLLIYK CGGIGKRTVK KFEKEAAEMG KGSVRYAWVL 60
GKLKAQCERG ITIDILWKFE TSKHYVTIID APGHRDFIKN MITGTSQADC AVLIVAAGVG 120
EFEAGISKNE QTREHALLAY TLGVKQLIAG VNKMDSTEPP YSQKRYEEIV KEVGTYIKKI 180
GYNPDTVAFV SISGWNGDNV LEPSAYMPWF KGWKVTRIDG SARGTTLLEA LDCILPPTHP 240
TDKPLRLPLQ DVYKTGSIGT VPVGRVETGV LKPGMVVTFA PVNVTEVVKS VEMHHEALSE 300
APGDNVRFDV KNVSVKDVRR GNVAGDSKND PMEAAGFTAQ VTIPNHPGQI SAGYAPAVDC 360
HTAHILSLKI DSRSGKNLED DPKFSRSGDA AIVDMVPGKP MCAGSFFHCP PLGCFAVCDM 420
RQTVAVGVIK AVDKKAVGAG KVTKSAQKAQ KAK 453 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; IEA:InterPro.
 GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
 GO:0006184; P:GTP catabolic process; IEA:GOC. 
Interpro
 IPR000795; EF_GTP-bd_dom.
 IPR027417; P-loop_NTPase.
 IPR009001; Transl_elong_EF1A/Init_IF2_C.
 IPR004539; Transl_elong_EF1A_euk/arc.
 IPR004161; Transl_elong_EFTu/EF1A_2.
 IPR004160; Transl_elong_EFTu/EF1A_C.
 IPR009000; Transl_elong_init/rib_B-barrel. 
Pfam
 PF00009; GTP_EFTU
 PF03144; GTP_EFTU_D2
 PF03143; GTP_EFTU_D3 
SMART
  
PROSITE
  
PRINTS
 PR00315; ELONGATNFCT.