CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023811
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 WD repeat domain phosphoinositide-interacting protein 4 
Protein Synonyms/Alias
 WIPI-4; WD repeat-containing protein 45 
Gene Name
 WDR45 
Gene Synonyms/Alias
 WDRX1; WDRXI4; WIPI4; JM5 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
146FDTRDNPKGLCDLCPubiquitination[1]
157DLCPSLEKQLLVFPGubiquitination[1]
226RLFDTQSKEKLVELRubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
 REPEAT 4 42 WD 1.
 REPEAT 190 230 WD 2.
 REPEAT 235 274 WD 3.  
Keyword
 Alternative splicing; Complete proteome; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 360 AA 
Protein Sequence
MTQQPLRGVT SLRFNQDQSC FCCAMETGVR IYNVEPLMEK GHLDHEQVGS MGLVEMLHRS 60
NLLALVGGGS SPKFSEISAV LIWDDAREGK DSKEKLVLEF TFTKPVLSVR MRHDKIVIVL 120
KNRIYVYSFP DNPRKLFEFD TRDNPKGLCD LCPSLEKQLL VFPGHKCGSL QLVDLASTKP 180
GTSSAPFTIN AHQSDIACVS LNQPGTVVAS ASQKGTLIRL FDTQSKEKLV ELRRGTDPAT 240
LYCINFSHDS SFLCASSDKG TVHIFALKDT RLNRRSALAR VGKVGPMIGQ YVDSQWSLAS 300
FTVPAESACI CAFGRNTSKN VNSVIAICVD GTFHKYVFTP DGNCNREAFD VYLDICDDDD 360
F 361 
Gene Ontology
 GO:0005737; C:cytoplasm; IBA:RefGenome.
 GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IBA:RefGenome.
 GO:0032266; F:phosphatidylinositol-3-phosphate binding; IBA:RefGenome.
 GO:0000045; P:autophagic vacuole assembly; IBA:RefGenome. 
Interpro
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS