UniProt Accession

 HBB2_MOUSE; P02089; Q5D0E8 

Genbank Protein ID

 V00722; X14061; BC027434; BC032264 

Genbank Nucleotide ID

 CAA24101.1; CAA32225.1; AAH27434.1; AAH32264.1 

Protein Name

 Hemoglobin subunit beta-2 

Protein Synonyms/Alias

 Beta-2-globin; Hemoglobin beta-2 chain; Hemoglobin beta-minor chain 

Gene Name

 Hbb-b2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
9	VHLTDAEKSAVSCLW	ubiquitination	[1]
18	AVSCLWAKVNPDEVG	acetylation	[2, 3]
18	AVSCLWAKVNPDEVG	succinylation	[3]
18	AVSCLWAKVNPDEVG	ubiquitination	[1]
60	SAIMGNPKVKAHGKK	acetylation	[3]
60	SAIMGNPKVKAHGKK	succinylation	[3]
60	SAIMGNPKVKAHGKK	ubiquitination	[1]
67	KVKAHGKKVITAFNE	phosphoglycerylation	[4]
67	KVKAHGKKVITAFNE	ubiquitination	[1]
77	TAFNEGLKNLDNLKG	ubiquitination	[1]
83	LKNLDNLKGTFASLS	phosphoglycerylation	[4]
83	LKNLDNLKGTFASLS	ubiquitination	[1]
96	LSELHCDKLHVDPEN	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Functional lysine modification by an intrinsically reactive primary glycolytic metabolite.
 Moellering RE, Cravatt BF.
 Science. 2013 Aug 2;341(6145):549-53. [PMID: 23908237] 

Functional Description

 Involved in oxygen transport from the lung to the various peripheral tissues. 

Sequence Annotation

 METAL 64 64 Iron (heme distal ligand).
 METAL 93 93 Iron (heme proximal ligand).
 MOD_RES 36 36 Phosphotyrosine.
 MOD_RES 42 42 Phosphotyrosine.
 MOD_RES 45 45 Phosphoserine.  

Keyword

 3D-structure; Complete proteome; Heme; Iron; Metal-binding; Oxygen transport; Phosphoprotein; Polymorphism; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 147 AA 

Protein Sequence

Gene Ontology

 GO:0005833; C:hemoglobin complex; IMP:MGI.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0019825; F:oxygen binding; IMP:MGI.
 GO:0005344; F:oxygen transporter activity; IEA:UniProtKB-KW.
 GO:0048821; P:erythrocyte development; IGI:MGI.
 GO:0045639; P:positive regulation of myeloid cell differentiation; IMP:MGI.
 GO:0045646; P:regulation of erythrocyte differentiation; IMP:MGI. 

Interpro

 IPR000971; Globin.
 IPR009050; Globin-like.
 IPR012292; Globin_dom.
 IPR002337; Haemoglobin_b. 

Pfam

 PF00042; Globin 

SMART

  

PROSITE

 PS01033; GLOBIN 

PRINTS

 PR00814; BETAHAEM.