| Tag | Content |
|---|
| CPLM ID | CPLM-016046 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Sodium-dependent phosphate transporter 2 |
Protein Synonyms/Alias | Phosphate transporter 2; PiT-2; Solute carrier family 20 member 2; Type III sodium-dependent phosphate transporter |
Gene Name | Slc20a2 |
Gene Synonyms/Alias | Pit2 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 248 | KIAGRLEKESALSRA | ubiquitination | [1] | | 278 | FKELPGAKPSDDSAV | ubiquitination | [1] | | 360 | LYKDLLHKIHVDRGS | ubiquitination | [1] | | 370 | VDRGSEEKPTQENNY | ubiquitination | [1] | | 416 | SAPEDSEKLVGDSVS | ubiquitination | [1] | | 426 | GDSVSYSKKRLRYDS | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. In vitro, sodium-dependent phosphate uptake is not siginificantly affected by acidic and alkaline conditions, however sodium-independent phosphate uptake occurs at acidic conditions. May play a role in extracellular matrix, cartilage and vascular calcification. Functions as a retroviral receptor (By similarity). |
Sequence Annotation | MOD_RES 268 268 Phosphoserine.
CARBOHYD 81 81 N-linked (GlcNAc...) (Potential). |
Keyword | Cell membrane; Complete proteome; Glycoprotein; Host-virus interaction; Ion transport; Membrane; Phosphate transport; Phosphoprotein; Receptor; Reference proteome; Sodium; Sodium transport; Symport; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 656 AA |
Protein Sequence | MAMDGYLWMV ILGFIIAFIL AFSVGANDVA NSFGTAVGSG VVTLRQACIL ASIFETTGSV 60
LLGAKVGETI RKGIIDVNLY NETVETLMAG EVSAMVGSAV WQLIASFLRL PISGTHCIVG 120
STIGFSLVAI GPKGVQWMEL VKIVASWFIS PLLSGFMSGV LFILIRMFIL TKEDPVPNGL 180
QALPLFYAAT IAINVFSIMY TGAPVLGLSL PIWAIALISF GVALLFAFFV WLFVCPWMKR 240
KIAGRLEKES ALSRASDESL RKVQEAESPG FKELPGAKPS DDSAVPLTSL AGEAVGASEG 300
TSAGNHPRAS YGRALSMTHG SAKSPISNGT FGFEGHMRND GHVYHTVHKD SGLYKDLLHK 360
IHVDRGSEEK PTQENNYRLL RRNNSYTCYT AAICGMPVHT TFRASDTSSA PEDSEKLVGD 420
SVSYSKKRLR YDSYSSYCNA VAEAEIEAEE GGVEMRLASE LADPDRPHED PTEEEKEEKD 480
SAEVHLLFHF LQVLTACFGS FAHGGNDVSN AIGPLVALWL IYQQGGVTQE AATPVWLLFY 540
GGVGICTGLW VWGRRVIQTM GKDLTPITPS SGFTIELASA FTVVIASNIG LPVSTTHCKV 600
GSVVAVGWIR SRKAVDWRLF RNIFVAWFVT VPVAGLFSAA IMALLMYICG LFSSSR 656 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0005315; F:inorganic phosphate transmembrane transporter activity; IEA:InterPro. GO:0015293; F:symporter activity; IEA:UniProtKB-KW. GO:0006817; P:phosphate ion transport; IEA:UniProtKB-KW. GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW. GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |