CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014859
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Inositol-3-phosphate synthase 1 
Protein Synonyms/Alias
 IPS 1; Myo-inositol 1-phosphate synthase; MI-1-P synthase; MIP synthase 
Gene Name
 Isyna1 
Gene Synonyms/Alias
 Ino1 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
393VPYVGDSKRALDEYTacetylation[1]
516ERPFPGIKPEEVKATacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds (By similarity). 
Sequence Annotation
  
Keyword
 Complete proteome; Cytoplasm; Inositol biosynthesis; Isomerase; Lipid biosynthesis; Lipid metabolism; NAD; Phospholipid biosynthesis; Phospholipid metabolism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 557 AA 
Protein Sequence
MEPAAEILVD SPDVIFGPEA IEARYEYRTT RVSREGGVLR VRPTATRFTF RTARQVPRLG 60
VMLVGWGGNN GSTLTAAVLA NRLRLTWPTR TGRKEANYYG SLTQAGTVNL GLDGDGREVF 120
VPFSALLPMV APNDLVFDGW DISSLNLAEA MRRAQVLDCG LQEQLWPHME SLRPRPSVYI 180
PEFIAANQTA RADNLIPGTR AQQLEQIRKD IRDFRSSAGL DKVIVLWTAN TERFCEVVPG 240
RNDTAENLLR TIQLGLEVSP STLFAVASIL EGCAFLNGSP QNTLVPGALE LASQRHVFVG 300
GDDFKSGQTK VKSVLVDFLI GSGLKTMSIV SYNHLGNNDG QNLSAPLQFR SKEVTKSSVV 360
DDMVQSNRVL YAPGEEPDHC VVIKYVPYVG DSKRALDEYT SELMLGGTNT LVLHNTCEDS 420
LLAAPIMLDL VLLTELCQRV SFCTDSDPEP QGFHPVLSVL SFLFKAPLVP PGSPVVNALF 480
RQRSCIENIF RACVGLPPQN HMLLEHKMER PFPGIKPEEV KATSPLPCKK ESTPATNGCT 540
GDANGHTQAP TPELSTA 557 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004512; F:inositol-3-phosphate synthase activity; IEA:EC.
 GO:0006021; P:inositol biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-KW. 
Interpro
 IPR002587; Myo-inos-1-P_Synthase.
 IPR013021; Myo-inos-1-P_Synthase_GAPDH.
 IPR016040; NAD(P)-bd_dom. 
Pfam
 PF01658; Inos-1-P_synth
 PF07994; NAD_binding_5 
SMART
  
PROSITE
  
PRINTS