| Tag | Content |
|---|
| CPLM ID | CPLM-000190 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | RNA polymerase II elongation factor ELL |
Protein Synonyms/Alias | Eleven-nineteen lysine-rich leukemia protein |
Gene Name | Ell |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 129 | ATDDSYQKARQSMAQ | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre- initiation complex and early elongation (By similarity). |
Sequence Annotation | MOD_RES 300 300 Phosphoserine (By similarity).
MOD_RES 542 542 Phosphoserine (By similarity). |
Keyword | Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 602 AA |
Protein Sequence | MAALKEARSY GLSCGRVSDG SRVSVFHVKL TDSALKAFES YRAHQDSVSL RPSIRFEGSQ 60
GHISIPQPDC PEEVRAFSFY LSNIGRDSPQ GSFDCIQQYV SSYGDVHLDC LGSIQDKVTV 120
CATDDSYQKA RQSMAQAEEE TRSRSAIVIK AGGRYMGKKV QFRKPAPGAA DAVPSRKRAT 180
PINLASAIRK SSGSGASSVV QRPFRDRVLH LLALRPYRKA ELLLRLQKDG LTQADKDTLD 240
SLLQQVASVN PKDGTCTLQD CMYKSLQKDW PGYSEGDRQL LKRMLMRKLC QPQNATTDSS 300
PPREHGRSAS PSQKRPTDFI DPLASKKPRI SHFTQRAQPT LNGKLGAPNG HETLLPAPGP 360
TPSDTLSSSH LPPRLEPPRT HDPLADVSND LGHSTQDYKH QEATPAPAPH LGLPLLTDFP 420
QAEQPTSSSH THSRPKKKSK KHKDKERPPE ERPPAPQPDA PTAPALPPDA PGLNGACDNE 480
PTSSSETPDY LLKYPAISSS EQRQSYKNDF NAEYSEYRSL HARIEQITRR FTQLDAQLRQ 540
LSQGSDEYET TRGQILQEYR KIKKTNTNYS CEKRRCEYLH RKLAHIKRLI AEYDQRQLQA 600
WP 602 |
Gene Ontology | GO:0015030; C:Cajal body; IEA:UniProtKB-SubCell. GO:0016607; C:nuclear speck; ISS:UniProtKB. GO:0008023; C:transcription elongation factor complex; IEA:InterPro. GO:0019902; F:phosphatase binding; ISS:UniProtKB. GO:0001701; P:in utero embryonic development; IMP:MGI. GO:0010923; P:negative regulation of phosphatase activity; ISS:UniProtKB. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006368; P:transcription elongation from RNA polymerase II promoter; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |