CPLM-002786

Genbank Nucleotide ID

Tropomyosin alpha-1 chain

Protein Synonyms/Alias

Alpha-tropomyosin; Tropomyosin-1

Homo sapiens (Human)

Position	Peptide	Type	References
118	QKLEEAEKAADESER	ubiquitination	[1]
149	EIQEIQLKEAKHIAE	acetylation	[2]
213	SLEAQAEKYSQKEDR	ubiquitination	[3]
226	DRYEEEIKVLSDKLK	ubiquitination	[3]

[1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
[2] Regulation of cellular metabolism by protein lysine acetylation.
Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
[3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]

Functional Description

Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.

MOD_RES 1 1 N-acetylmethionine.
MOD_RES 283 283 Phosphoserine; by DAPK1.
CROSSLNK 77 77 Glycyl lysine isopeptide (Lys-Gly)

Acetylation; Actin-binding; Alternative splicing; Cardiomyopathy; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Disease mutation; Isopeptide bond; Muscle protein; Phosphoprotein; Reference proteome; Ubl conjugation.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0032059; C:bleb; IMP:BHF-UCL.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0031941; C:filamentous actin; IEA:Compara.
GO:0005862; C:muscle thin filament tropomyosin; TAS:ProtInc.
GO:0032587; C:ruffle membrane; IDA:BHF-UCL.
GO:0001725; C:stress fiber; IDA:BHF-UCL.
GO:0003779; F:actin binding; TAS:BHF-UCL.
GO:0005200; F:structural constituent of cytoskeleton; TAS:BHF-UCL.
GO:0008307; F:structural constituent of muscle; TAS:ProtInc.
GO:0060048; P:cardiac muscle contraction; IMP:BHF-UCL.
GO:0034614; P:cellular response to reactive oxygen species; IEP:BHF-UCL.
GO:0001701; P:in utero embryonic development; IEA:Compara.
GO:0030049; P:muscle filament sliding; ISS:BHF-UCL.
GO:0030336; P:negative regulation of cell migration; ISS:BHF-UCL.
GO:0032781; P:positive regulation of ATPase activity; ISS:BHF-UCL.
GO:0045785; P:positive regulation of cell adhesion; ISS:BHF-UCL.
GO:0003065; P:positive regulation of heart rate by epinephrine; ISS:BHF-UCL.
GO:0051496; P:positive regulation of stress fiber assembly; ISS:BHF-UCL.
GO:0006937; P:regulation of muscle contraction; TAS:ProtInc.
GO:0031529; P:ruffle organization; ISS:BHF-UCL.
GO:0045214; P:sarcomere organization; IMP:BHF-UCL.
GO:0055010; P:ventricular cardiac muscle tissue morphogenesis; IMP:BHF-UCL.
GO:0042060; P:wound healing; ISS:BHF-UCL.

IPR000533; Tropomyosin.

PF00261; Tropomyosin

PS00326; TROPOMYOSIN

PR00194; TROPOMYOSIN.