CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022643
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Bile salt export pump 
Protein Synonyms/Alias
 ATP-binding cassette sub-family B member 11; Sister of P-glycoprotein 
Gene Name
 Abcb11 
Gene Synonyms/Alias
 Bsep; Spgp 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
12VILRSVKKFGEENHAubiquitination[1]
30DGFHNNDKKSRLQDKubiquitination[1]
272KFTELELKAYAKAGSubiquitination[1]
276LELKAYAKAGSIADEubiquitination[1]
299AAFGGENKEVERYEKubiquitination[1]
306KEVERYEKNLMFAQRubiquitination[1]
412CMSGDGYKLDRIKGEubiquitination[1]
417GYKLDRIKGEIEFHNubiquitination[1]
446NNLSMVIKPGETTAFubiquitination[1]
596LDNESEAKVQGALNKubiquitination[1]
702ASIRQRSKSQLSHLSubiquitination[1]
720PLAIGDHKSSYEDRKubiquitination[1]
727KSSYEDRKDNDVLVEubiquitination[1]
788KTFSLVDKEQQRSEIubiquitination[1]
837RLRKFGFKAMLRQDIubiquitination[1]
851IGWFDDLKNNPGVLTubiquitination[1]
930TGFASQDKEILEKAGubiquitination[1]
935QDKEILEKAGQITNEubiquitination[1]
961GVEGRFIKAFEVELEubiquitination[1]
1043SYTPSYAKAKISAARubiquitination[1]
1058FFQLLDRKPPIDVYSubiquitination[1]
1070VYSGAGEKWDNFQGKubiquitination[1]
1077KWDNFQGKIDFIDCKubiquitination[1]
1145MIDGHDSKKVNVQFLubiquitination[1]
1146IDGHDSKKVNVQFLRubiquitination[1]
1175CSIMDNIKYGDNTKEubiquitination[1]
1181IKYGDNTKEISVERAubiquitination[1]
1193ERAIAAAKQAQLHDFubiquitination[1]
1207FVMSLPEKYETNVGIubiquitination[1]
1238RAIVRDPKILLLDEAubiquitination[1]
1255ALDTESEKTVQLALDubiquitination[1]
1263TVQLALDKAREGRTCubiquitination[1]
1307HKKLMDQKGAYYKLVubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes. 
Sequence Annotation
 DOMAIN 62 385 ABC transmembrane type-1 1.
 DOMAIN 420 656 ABC transporter 1.
 DOMAIN 755 1043 ABC transmembrane type-1 2.
 DOMAIN 1078 1316 ABC transporter 2.
 NP_BIND 455 462 ATP 1 (Potential).
 NP_BIND 1113 1120 ATP 2 (Potential).
 REGION 651 674 Interaction with HAX1 (By similarity).
 MOD_RES 692 692 Phosphoserine.
 MOD_RES 696 696 Phosphoserine.
 MOD_RES 703 703 Phosphoserine.
 MOD_RES 709 709 Phosphoserine.
 CARBOHYD 109 109 N-linked (GlcNAc...) (Potential).
 CARBOHYD 116 116 N-linked (GlcNAc...) (Potential).
 CARBOHYD 122 122 N-linked (GlcNAc...) (Potential).
 CARBOHYD 125 125 N-linked (GlcNAc...) (Potential).  
Keyword
 ATP-binding; Complete proteome; Glycoprotein; Membrane; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1321 AA 
Protein Sequence
MSDSVILRSV KKFGEENHAF ESDGFHNNDK KSRLQDKKKG EGARVGFFEL FRFSSSKDNW 60
LMFMGSVCAL LHGMAQPGMI IVFGILTDIF VEYDIERQEL SIPEKVCMNN TIVWINSSFN 120
QNMTNGTSCG LVDINSEVIK FSGIYAGVGV AVLILGYFQI RLWVITGARQ IRKMRKFYFR 180
RIMRMEIGWF DCTSVGELNS RFSDDINKID EAIADQMALF LQRLSTALSG LLLGFYRGWK 240
LTLVILAVSP LIGIGAAVIG LSVAKFTELE LKAYAKAGSI ADEVLSSIRT VAAFGGENKE 300
VERYEKNLMF AQRWGIWKGM VMGFFTGYMW CLIFFCYALA FWYGSRLVLD EGEYTPGTLI 360
QIFLCVIIAA MNIGNASSCL EIFSTGCSAA SSIFQTIDRQ PVMDCMSGDG YKLDRIKGEI 420
EFHNVTFHYP SRPEVKILNN LSMVIKPGET TAFVGSSGAG KSTALQLIQR FYDPCEGMVT 480
LDGHDIRSLN IRWLRDQIGI VEQEPVLFST TIAENIRLGR EEATMEDIVQ AAKDANAYNF 540
IMALPQQFDT LVGEGGGQMS GGQKQRVAIA RALIRKPKIL LLDMATSALD NESEAKVQGA 600
LNKIQHGHTI ISVAHRLSTV RSADVIIGFE HGTAVERGTH EELLERKGVY FMLVTLQSQE 660
DNTHKETGIK GKDTTEGDTP ERTFSRGSYQ DSLRASIRQR SKSQLSHLSH EPPLAIGDHK 720
SSYEDRKDND VLVEEVEPAP VRRILKYNIS EWPYILVGAL CAAINGAVTP IYSLLFSQIL 780
KTFSLVDKEQ QRSEIYSMCL FFVILGCVSL FTQFLQGYNF AKSGELLTKR LRKFGFKAML 840
RQDIGWFDDL KNNPGVLTTR LATDASQVQG ATGSQVGMMV NSFTNIFVAV LIAFLFNWKL 900
SLVISVFFPF LALSGAVQTK MLTGFASQDK EILEKAGQIT NEALSNIRTV AGIGVEGRFI 960
KAFEVELEKS YKTAIRKANV YGLCYAFSQG ISFLANSAAY RYGGYLIVYE DLNFSYVFRV 1020
VSSIAMSATA VGRTFSYTPS YAKAKISAAR FFQLLDRKPP IDVYSGAGEK WDNFQGKIDF 1080
IDCKFTYPSR PDIQVLNGLS VSVDPGQTLA FVGSSGCGKS TSIQLLERFY DPDQGTVMID 1140
GHDSKKVNVQ FLRSNIGIVS QEPVLFDCSI MDNIKYGDNT KEISVERAIA AAKQAQLHDF 1200
VMSLPEKYET NVGIQGSQLS RGEKQRIAIA RAIVRDPKIL LLDEATSALD TESEKTVQLA 1260
LDKAREGRTC IVIAHRLSTI QNSDIIAVMS QGVVIEKGTH KKLMDQKGAY YKLVITGAPI 1320
S 1321 
Gene Ontology
 GO:0016324; C:apical plasma membrane; IBA:RefGenome.
 GO:0000139; C:Golgi membrane; IBA:RefGenome.
 GO:0016021; C:integral to membrane; IBA:RefGenome.
 GO:0046581; C:intercellular canaliculus; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0042626; F:ATPase activity, coupled to transmembrane movement of substances; IBA:RefGenome.
 GO:0015126; F:canalicular bile acid transmembrane transporter activity; IBA:RefGenome. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR003439; ABC_transporter-like.
 IPR017871; ABC_transporter_CS.
 IPR017940; ABC_transporter_type1.
 IPR001140; ABC_transptr_TM_dom.
 IPR011527; ABC_transptrTM_dom_typ1.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00664; ABC_membrane
 PF00005; ABC_tran 
SMART
 SM00382; AAA 
PROSITE
 PS50929; ABC_TM1F
 PS00211; ABC_TRANSPORTER_1
 PS50893; ABC_TRANSPORTER_2 
PRINTS