CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033809
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Exportin 6, isoform CRA_a 
Protein Synonyms/Alias
 Exportin-6 
Gene Name
 XPO6 
Gene Synonyms/Alias
 hCG_17360 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
274GCDIRARKMASVNGSubiquitination[1]
343DNNAHTVKSRLEELDubiquitination[2]
703SALRLVDKAQVLVCRubiquitination[1]
752SRDYRNLKPSAVAPQubiquitination[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Nucleus; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1111 AA 
Protein Sequence
MTEFFHDCTT NERKREIEEL LNNFAQQIGA WRFCLYFLSS TRNDYVMMYS LTVFENLINK 60
MWLGVPSQDK MEIRSCLPKL LLAHHKTLPY FIRNKLCKVI VDIGRQDWPM FYHDFFTNIL 120
QLIQSPVTTP LGLIMLKTTS EELACPREDL SVARKEELRK LLLDQVQTVL GLLTGILETV 180
WDKHSVTAAT PPPSPTSGES GDLLSNLLQS PSSAKLLNQP IPILDVESEY ICSLALECLA 240
HLFSWIPLSA SITPSLLTTI FHFARFGCDI RARKMASVNG SSQNCVSGQE RGRLGVLAMS 300
CINELMSKNC VPMEFEEYLL RMFQQTFYLL QKITKDNNAH TVKSRLEELD ESYIEKFTDF 360
LRLFVSVHLR RIESYSQFPV VEFLTLLFKY TFHQPTHEGY FSCLDIWTLF LDYLTSKIKS 420
RLGDKEAVLN RYEDALVLLL TEVLNRIQFR YNQAQLEELD DETLDDDQQT EWQRYLRQSL 480
EVVAKVMELL PTHAFSTLFP VLQDNLEVYL GLQQFIVTSG SGHRLNITAE NDCRRLHCSL 540
RDLSSLLQAV GRLAEYFIGD VFAARFNDAL TVVERLVKVT LYGSQIKLYN IETAVPSVLK 600
PDLIDVHAQS LAALQAYSHW LAQYCSEVHR QNTQQFVTLI STTMDAITPL ISTKVQDKLL 660
LSACHLLVSL ATTVRPVFLI SIPAVQKVFN RITDASALRL VDKAQVLVCR ALSNILLLPW 720
PNLPENEQQW PVRSINHASL ISALSRDYRN LKPSAVAPQR KMPLDDTKLI IHQTLSVLED 780
IVENISGEST KSRQICYQSL QESVQVSLAL FPAFIHQSDV TDEMLSFFLT LFRGLRVQMG 840
VPFTEQIIQT FLNMFTREQL AESILHEGST GCRVVEKFLK ILQVVVQEPG QVFKPFLPSI 900
IALCMEQVYP IIAERPSPDV KAELFELLFR TLHHNWRYFF KSTVLASVQR GIAEEQMENE 960
PQFSAIMQAF GQSFLQPDIH LFKQNLFYLE TLNTKQKLYH KKIFRTAMLF QFVNVLLQVL 1020
VHKSHDLLQE EIGIAIYNMA SVDFDGFFAA FLPEFLTSCD GVDANQKSVL GRNFKMDRDL 1080
PSFTQNVHRL VNDLRYYRLC NDSLPPGTVK L 1111 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005643; C:nuclear pore; IEA:InterPro.
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0008565; F:protein transporter activity; IEA:InterPro.
 GO:0006886; P:intracellular protein transport; IEA:InterPro. 
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR013598; Exportin-1/Importin-b-like.
 IPR001494; Importin-beta_N. 
Pfam
 PF03810; IBN_N
 PF08389; Xpo1 
SMART
 SM00913; IBN_N 
PROSITE
 PS50166; IMPORTIN_B_NT 
PRINTS