CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023639
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 A-kinase anchor protein 2 
Protein Synonyms/Alias
 AKAP-2; AKAP-KL; Protein kinase A-anchoring protein 2; PRKA2 
Gene Name
 AKAP2 
Gene Synonyms/Alias
 KIAA0920; PRKA2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
124KSFKDFQKGFSSTDGacetylation[1]
660SKRGPLSKLWAEDGEubiquitination[2]
679RAVLTVVKDDDHGILubiquitination[2]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Binds to regulatory subunit (RII) of protein kinase A. May be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by cAMP (By similarity). 
Sequence Annotation
 REGION 566 579 PKA-RII subunit binding domain.
 MOD_RES 121 121 Phosphoserine.
 MOD_RES 152 152 Phosphoserine.
 MOD_RES 336 336 Phosphoserine (By similarity).
 MOD_RES 393 393 Phosphoserine.
 MOD_RES 461 461 Phosphoserine.
 MOD_RES 631 631 Phosphoserine.
 MOD_RES 720 720 Phosphoserine.
 MOD_RES 748 748 Phosphoserine.
 MOD_RES 778 778 Phosphoserine (By similarity).  
Keyword
 Alternative splicing; Coiled coil; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 859 AA 
Protein Sequence
MAEAELHKER LQAIAEKRKR QTEIEGKRQQ LDEQILLLQH SKSKVLREKW LLQGIPAGTA 60
EEEEARRRQS EEDEFRVKQL EDNIQRLEQE IQTLESEESQ ISAKEQIILE KLKETEKSFK 120
DFQKGFSSTD GDAVNYISSQ LPDLPILCSR TAEPSPGQDG TSRAAGVGWE NVLLKEGESA 180
SNATETSGPD MTIKKPPQLS EDDIWLKSEG DNYSATLLEP AASSLSPDHK NMEIEVSVAE 240
CKSVPGITST PHPMDHPSAF YSPPHNGLLT DHHESLDNDV AREIRYLDEV LEANCCDSAV 300
DGTYNGTSSP EPGAVVLVGG LSPPVHEATQ PEPTERTASR QAPPHIELSN SSPDPMAEAE 360
RTNGHSPSQP RDALGDSLQV PVSPSSTTSS RCSSRDGEFT LTTLKKEAKF ELRAFHEDKK 420
PSKLFEDDEH EKEQYCIRKV RPSEEMLELE KERRELIRSQ AVKKNPGIAA KWWNPPQEKT 480
IEEQLDEEHL ESHKKYKERK ERRAQQEQLL LQKQLQQQQQ QPPSQLCTAP ASSHERASMI 540
DKAKEDIVTE QIDFSAARKQ FQLMENSRQA VAKGQSTPRL FSIKPFYRPL GSVNSDKPLT 600
NPRPPSVGGP PEDSGASAAK GQKSPGALET PSAAGSQGNT ASQGKEGPYS EPSKRGPLSK 660
LWAEDGEFTS ARAVLTVVKD DDHGILDQFS RSVNVSLTQE ELDSGLDELS VRSQDTTVLE 720
TLSNDFSMDN ISDSGASNET TNALQENSLA DFSLPQTPQT DNPSEGRGEG VSKSFSDHGF 780
YSPSSTLGDS PLVDDPLEYQ AGLLVQNAIQ QAIAEQVDKA VSKTSRDGAE QQGPEATVEE 840
AEAAAFGSEK PQSMFEPPQV SSPVQEKRDV LPKILPAEDR ALRERGPPQP LPAVQPSGPI 900
NMEETRPEGS YFSKYSEAAE LRSTASLLAT QESDVMVGPF KLRSRKQRTL SMIEEEIRAA 960
QEREEELKRQ RQVLQSTQSP RTKNAPSLPS RTCYKTAPGK IEKVKPPPSP TTEGPSLQPD 1020
LAPEEAAGTQ RPKNLMQTLM EDYETHKSKR RERMDDSSYT SKLLSCKVTS EVLEATRVNR 1080
RKSALALRWE AGIYANQEEE DNE 1103 
Gene Ontology
 GO:0019899; F:enzyme binding; NAS:UniProtKB. 
Interpro
 IPR018459; RII_binding_1. 
Pfam
 PF10522; RII_binding_1 
SMART
  
PROSITE
  
PRINTS