UniProt Accession

 EVGA_ECOLI; P0ACZ4; P30854 

Genbank Protein ID

 D14008; D11142; U00096; AP009048 

Genbank Nucleotide ID

 BAA03107.1; BAA01918.1; AAC75428.1; BAA16240.1 

Protein Name

 Positive transcription regulator EvgA 

Protein Synonyms/Alias

  

Gene Name

 evgA 

Gene Synonyms/Alias

 b2369; JW2366 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
89	KNDHFYGKHCADAGA	acetylation	[1]
140	SLTSDQQKLDSLSKQ	acetylation	[1]
146	QKLDSLSKQEISVMR	acetylation	[1]
159	MRYILDGKDNNDIAE	acetylation	[1]
167	DNNDIAEKMFISNKT	acetylation	[1]
173	EKMFISNKTVSTYKS	acetylation	[1]
179	NKTVSTYKSRLMEKL	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Member of the two-component regulatory system EvgS/EvgA. Regulates the expression of emrKY operon and yfdX. Seems also to control expression of at least one other multidrug efflux operon. 

Sequence Annotation

 DOMAIN 1 117 Response regulatory.
 DOMAIN 137 202 HTH luxR-type.
 DNA_BIND 161 180 H-T-H motif (By similarity).
 MOD_RES 52 52 4-aspartylphosphate (By similarity).  

Keyword

 3D-structure; Activator; Complete proteome; Cytoplasm; DNA-binding; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Two-component regulatory system. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 204 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0000156; F:phosphorelay response regulator activity; IEA:InterPro.
 GO:0043565; F:sequence-specific DNA binding; IDA:EcoCyc.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0035556; P:intracellular signal transduction; IEA:GOC.
 GO:0006355; P:regulation of transcription, DNA-dependent; IMP:EcoCyc.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR011006; CheY-like_superfamily.
 IPR016032; Sig_transdc_resp-reg_C-effctor.
 IPR001789; Sig_transdc_resp-reg_receiver.
 IPR000792; Tscrpt_reg_LuxR_C.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF00196; GerE
 PF00072; Response_reg 

SMART

 SM00421; HTH_LUXR
 SM00448; REC 

PROSITE

 PS00622; HTH_LUXR_1
 PS50043; HTH_LUXR_2
 PS50110; RESPONSE_REGULATORY 

PRINTS

 PR00038; HTHLUXR.