UniProt Accession

 1433F_RAT; P68511; P11576; P70198 

Genbank Protein ID

 D17445; BC081825 

Genbank Nucleotide ID

 BAA04259.1; AAH81825.1 

Protein Name

 14-3-3 protein eta 

Protein Synonyms/Alias

  

Gene Name

 Ywhah 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
69	VISSIEQKTMADGNE	acetylation	[1]
69	VISSIEQKTMADGNE	ubiquitination	[2]
77	TMADGNEKKLEKVKA	acetylation	[1]
142	AEVASGEKKNSVVEA	acetylation	[1]
142	AEVASGEKKNSVVEA	ubiquitination	[2]
143	EVASGEKKNSVVEAS	ubiquitination	[2]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (By similarity). 

Sequence Annotation

 MOD_RES 2 2 N-acetylglycine (By similarity).
 MOD_RES 25 25 Phosphoserine (By similarity).
 MOD_RES 59 59 Phosphoserine (By similarity).
 MOD_RES 117 117 Phosphotyrosine (By similarity).  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 246 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0044325; F:ion channel binding; ISS:BHF-UCL.
 GO:0017080; F:sodium channel regulator activity; ISS:BHF-UCL.
 GO:0006713; P:glucocorticoid catabolic process; IEA:Compara.
 GO:0042921; P:glucocorticoid receptor signaling pathway; IEA:Compara.
 GO:0006886; P:intracellular protein transport; IEA:Compara.
 GO:0050774; P:negative regulation of dendrite morphogenesis; IEA:Compara.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IEA:Compara.
 GO:2000649; P:regulation of sodium ion transmembrane transporter activity; ISS:BHF-UCL. 

Interpro

 IPR000308; 14-3-3.
 IPR023409; 14-3-3_CS.
 IPR023410; 14-3-3_domain. 

Pfam

 PF00244; 14-3-3 

SMART

 SM00101; 14_3_3 

PROSITE

 PS00796; 1433_1
 PS00797; 1433_2 

PRINTS

 PR00305; 1433ZETA.