UniProt Accession

 A2AIW9_MOUSE; A2AIW9 

Genbank Protein ID

 AL732541; CH466542 

Genbank Nucleotide ID

 EDL08311.1 

Protein Name

 Mitochondrial-processing peptidase subunit alpha 

Protein Synonyms/Alias

 Peptidase (Mitochondrial processing) alpha, isoform CRA_a 

Gene Name

 Pmpca 

Gene Synonyms/Alias

 mCG_18769 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
63	ATVDGQEKFETKVTT	acetylation	[1]
63	ATVDGQEKFETKVTT	succinylation	[1]
67	GQEKFETKVTTLDNG	acetylation	[1]
67	GQEKFETKVTTLDNG	succinylation	[1]
298	QYTGGIIKVERDMSN	acetylation	[1, 2, 3]
298	QYTGGIIKVERDMSN	succinylation	[1]

Reference

 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [3] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 441 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0046872; F:metal ion binding; IEA:InterPro.
 GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:InterPro. 

Interpro

 IPR011249; Metalloenz_LuxS/M16.
 IPR011237; Pept_M16_dom.
 IPR011765; Pept_M16_N.
 IPR001431; Pept_M16_Zn_BS.
 IPR007863; Peptidase_M16_C. 

Pfam

 PF00675; Peptidase_M16
 PF05193; Peptidase_M16_C 

SMART

  

PROSITE

 PS00143; INSULINASE 

PRINTS