CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019396
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Solute carrier family 35 member E1 
Protein Synonyms/Alias
  
Gene Name
 SLC35E1 
Gene Synonyms/Alias
 PSEC0038 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
345DANQQARKHLLPVTTubiquitination[1, 2]
358TTADLSSKERHRSPLubiquitination[1, 2, 3, 4]
367RHRSPLEKPHNGLLFubiquitination[1, 2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Putative transporter (By similarity). 
Sequence Annotation
 MOD_RES 352 352 Phosphothreonine (By similarity).
 MOD_RES 363 363 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 410 AA 
Protein Sequence
MAAAAVGAGH GAGGPGAASS SGGAREGARV AALCLLWYAL SAGGNVVNKV ILSAFPFPVT 60
VSLCHILALC AGLPPLLRAW RVPPAPPVSG PGPSPHPSSG PLLPPRFYPR YVLPLAFGKY 120
FASVSAHVSI WKVPVSYAHT VKATMPIWVV LLSRIIMKEK QSTKVYLSLI PIISGVLLAT 180
VTELSFDMWG LVSALAATLC FSLQNIFSKK VLRDSRIHHL RLLNILGCHA VFFMIPTWVL 240
VDLSAFLVSS DLTYVYQWPW TLLLLAVSGF CNFAQNVIAF SILNLVSPLS YSVANATKRI 300
MVITVSLIML RNPVTSTNVL GMMTAILGVF LYNKTKYDAN QQARKHLLPV TTADLSSKER 360
HRSPLEKPHN GLLFPQHGDY QYGRNNILTD HFQYSRQSYP NSYSLNRYDV 410 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0006810; P:transport; IEA:UniProtKB-KW. 
Interpro
 IPR000620; DMT.
 IPR004853; DUF250. 
Pfam
 PF00892; EamA
 PF03151; TPT 
SMART
  
PROSITE
  
PRINTS