UniProt Accession

 NXSB_PSSEM; Q90VW1; P01435 

Genbank Protein ID

 X16950; AB017929; AB017930; AB017931; AB098528; AB098529 

Genbank Nucleotide ID

 CAA34824.1; BAA75749.1; BAA75750.1; BAA75751.1; BAC78201.1; BAC78202.1 

Protein Name

 Erabutoxin b 

Protein Synonyms/Alias

 Short neurotoxin 1b 

Gene Name

 ETXB 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Pseudolaticauda semifasciata (Black-banded sea krait) (Laticaud 

NCBI Taxa ID

 8631 

Lysine Modification

Position	Peptide	Type	References
48	GESSCYHKQWSDFRG	acetylation	[1]
68	GCGCPTVKPGIKLSC	acetylation	[1]

Reference

 [1] Molecular conformation and function of erabutoxins as studied by nuclear magnetic resonance.
 Inagaki F, Tamiya N, Miyazawa T.
 Eur J Biochem. 1980 Aug;109(1):129-38. [PMID: 6773770] 

Functional Description

 Binds with high affinity to muscular nicotinic acetylcholine receptors (nAChRs), and with low affinity to neuronal alpha-7 nAChRs. Produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site. 

Sequence Annotation

 DISULFID 24 45
 DISULFID 38 62
 DISULFID 64 75
 DISULFID 76 81  

Keyword

 3D-structure; Acetylcholine receptor inhibiting toxin; Direct protein sequencing; Disulfide bond; Ion channel impairing toxin; Neurotoxin; Postsynaptic neurotoxin; Secreted; Signal; Toxin. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 83 AA 

Protein Sequence

Gene Ontology

 GO:0035792; C:other organism postsynaptic membrane; IEA:UniProtKB-KW.
 GO:0035821; P:modification of morphology or physiology of other organism; IEA:InterPro. 

Interpro

 IPR003571; Snake_toxin.
 IPR018354; Snake_toxin_BS. 

Pfam

 PF00087; Toxin_1 

SMART

  

PROSITE

 PS00272; SNAKE_TOXIN 

PRINTS