| Tag | Content |
|---|
| CPLM ID | CPLM-015199 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Complement C1s subcomponent |
Protein Synonyms/Alias | C1 esterase; Complement component 1 subcomponent s; Complement C1s subcomponent heavy chain; Complement C1s subcomponent light chain |
Gene Name | C1s |
Gene Synonyms/Alias | r-gsp |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 586 | VIQLRGAKLPITSLE | methylation | [1] |
|
Reference | [1] Post-translational modifications in the rat lumbar spinal cord in experimental autoimmune encephalomyelitis. Grant JE, Hu J, Liu T, Jain MR, Elkabes S, Li H. J Proteome Res. 2007 Jul;6(7):2786-91. [ PMID: 17567059] |
Functional Description | C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4 (By similarity). |
Sequence Annotation | DOMAIN 16 130 CUB 1.
DOMAIN 131 172 EGF-like; calcium-binding (Potential).
DOMAIN 175 290 CUB 2.
DOMAIN 292 356 Sushi 1.
DOMAIN 357 423 Sushi 2.
DOMAIN 438 680 Peptidase S1.
ACT_SITE 475 475 Charge relay system (By similarity).
ACT_SITE 529 529 Charge relay system (By similarity).
ACT_SITE 631 631 Charge relay system (By similarity).
METAL 60 60 Calcium (By similarity).
METAL 68 68 Calcium (By similarity).
METAL 113 113 Calcium (By similarity).
METAL 131 131 Calcium (By similarity).
METAL 132 132 Calcium; via carbonyl oxygen (By
METAL 134 134 Calcium (By similarity).
METAL 149 149 Calcium (By similarity).
METAL 150 150 Calcium; via carbonyl oxygen (By
METAL 153 153 Calcium; via carbonyl oxygen (By
MOD_RES 149 149 (3R)-3-hydroxyasparagine (By similarity).
CARBOHYD 174 174 N-linked (GlcNAc...) (Potential).
CARBOHYD 406 406 N-linked (GlcNAc...) (Potential).
DISULFID 65 83 By similarity.
DISULFID 135 147 By similarity.
DISULFID 143 156 By similarity.
DISULFID 158 171 By similarity.
DISULFID 175 202 By similarity.
DISULFID 234 251 By similarity.
DISULFID 294 341 By similarity.
DISULFID 321 354 By similarity.
DISULFID 359 403 By similarity.
DISULFID 386 421 By similarity.
DISULFID 425 549 Interchain (between heavy and light
DISULFID 595 618 By similarity.
DISULFID 627 659 By similarity. |
Keyword | Calcium; Complement pathway; Complete proteome; Disulfide bond; EGF-like domain; Glycoprotein; Hydrolase; Hydroxylation; Immunity; Innate immunity; Metal-binding; Protease; Reference proteome; Repeat; Serine protease; Signal; Sushi. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 688 AA |
Protein Sequence | MWCFVFFSLL ASFSAEPTMY GEILSPNYPQ AYPNEVVKTW DIEVPEGFGI HLYFTHLDME 60
LSENCAYDSV QIISGGIEEE RLCGQRTSKS PNSPTVEEFQ FPYNRLQVVF TSDFSNEERF 120
TGFAAYYSAV DVNECTDFTD VPCSHFCNNF IGGYFCSCPP EYFLHDDMRT CGVNCSGDVF 180
TALIGEIASP NYPNPYPENS RCEYQIRLQE GFRLVLTIRR EDFDVEPADS EGNCHDSLTF 240
AAKNQQFGPY CGNGFPGPLT IKTQSNTLDI VFQTDLTGQN KGWKLRYHGD PIPCPKEISA 300
NSIWEPEKAK YVFKDVVKIT CVDGFEVVEG NVGSTSFYST CQSNGQWSNS RLECQPVDCG 360
VPEPIENGKV EDPEDTVFGS VIHYTCEEPY YYMEQEEGGE YHCAANGSWV NDQLGVELPK 420
CIPVCGVPTE PFKVQQRIFG GYSTKIQSFP WQVYFESPRG GGALIDEYWV LTAAHVVEGN 480
SDPVMYVGST LLKIERLRNA QRLITERVII HPSWKQEDDL NTRTNFDNDI ALVQLKDPVK 540
MGPTVAPICL PETSSDYNPS EGDLGLISGW GRTENRTNVI QLRGAKLPIT SLEKCQQVKV 600
ENPKARSNDY VFTDNMICAG EKGVDSCEGD SGGAFALPVP NVKDPKFYVA GLVSWGKKCG 660
TYGIYTKVKN YVDWILKTMQ ENSGPKKD 688 |
Gene Ontology | GO:0005576; C:extracellular region; IDA:RGD. GO:0005509; F:calcium ion binding; IEA:InterPro. GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro. GO:0006958; P:complement activation, classical pathway; IEA:UniProtKB-KW. GO:0010001; P:glial cell differentiation; IEP:RGD. GO:0045087; P:innate immune response; IEA:UniProtKB-KW. GO:0006508; P:proteolysis; IEA:UniProtKB-KW. GO:0051591; P:response to cAMP; IEP:RGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |