UniProt Accession

 A2RTT4_MOUSE; A2RTT4 

Genbank Protein ID

 BC132630; BC138211; CH466539 

Genbank Nucleotide ID

 AAI32631.1; AAI38212.1; EDL21609.1 

Protein Name

 MCG4297 

Protein Synonyms/Alias

 Ubiquitin-conjugating enzyme E2N 

Gene Name

 Ube2n 

Gene Synonyms/Alias

 mCG_4297 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
10	GLPRRIIKETQRLLA	ubiquitination	[1]
24	AEPVPGIKAEPDESN	ubiquitination	[1]
68	EYPMAAPKVRFMTKI	ubiquitination	[1]
74	PKVRFMTKIYHPNVD	ubiquitination	[1]
82	IYHPNVDKLGRICLD	ubiquitination	[1]
92	RICLDILKDKWSPAL	ubiquitination	[1]
94	CLDILKDKWSPALQI	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

  

Sequence Annotation

  

Keyword

 Ligase; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 152 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IDA:MGI.
 GO:0031372; C:UBC13-MMS2 complex; IEA:Compara.
 GO:0035370; C:UBC13-UEV1A complex; IEA:Compara.
 GO:0000151; C:ubiquitin ligase complex; IEA:Compara.
 GO:0004842; F:ubiquitin-protein ligase activity; IDA:MGI.
 GO:0000729; P:DNA double-strand break processing; IEA:Compara.
 GO:0000724; P:double-strand break repair via homologous recombination; IEA:Compara.
 GO:0016574; P:histone ubiquitination; IEA:Compara.
 GO:0045739; P:positive regulation of DNA repair; IEA:Compara.
 GO:0031058; P:positive regulation of histone modification; IEA:Compara.
 GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IEA:Compara.
 GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Compara.
 GO:0051443; P:positive regulation of ubiquitin-protein ligase activity; IEA:Compara.
 GO:0006301; P:postreplication repair; IEA:Compara.
 GO:0070534; P:protein K63-linked ubiquitination; IEA:Compara.
 GO:0033182; P:regulation of histone ubiquitination; IEA:Compara.
 GO:0050852; P:T cell receptor signaling pathway; IEA:Compara.
 GO:0006511; P:ubiquitin-dependent protein catabolic process; IDA:MGI. 

Interpro

 IPR000608; UBQ-conjugat_E2.
 IPR023313; UBQ-conjugating_AS.
 IPR016135; UBQ-conjugating_enzyme/RWD. 

Pfam

 PF00179; UQ_con 

SMART

  

PROSITE

 PS00183; UBIQUITIN_CONJUGAT_1
 PS50127; UBIQUITIN_CONJUGAT_2 

PRINTS