UniProt Accession

 COQ6_HUMAN; Q9Y2Z9; B7Z3K8; Q53GG6; Q86U30; Q96CA1; Q96CK2 

Genbank Protein ID

 AF132944; AK296040; BX248000; AK222965; AC005480; CH471061; BC014181; BC014483 

Genbank Nucleotide ID

 AAD27719.1; BAH12244.1; CAD62332.1; BAD96685.1; EAW81148.1; AAH14181.1; AAH14483.1 

Protein Name

 Ubiquinone biosynthesis monooxygenase COQ6 

Protein Synonyms/Alias

 Coenzyme Q10 monooxygenase 6 

Gene Name

 COQ6 

Gene Synonyms/Alias

 CGI-10 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
78	GPKKVLEKLSETYSN	ubiquitination	[1, 2]
459	TNAVSPLKEQIMAFA	ubiquitination	[3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

  

Keyword

 Alternative splicing; Cell projection; Complete proteome; Deafness; Disease mutation; FAD; Flavoprotein; Golgi apparatus; Monooxygenase; Oxidoreductase; Polymorphism; Reference proteome; Ubiquinone biosynthesis. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 468 AA 

Protein Sequence

Gene Ontology

 GO:0042995; C:cell projection; IEA:UniProtKB-SubCell.
 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IDA:LIFEdb.
 GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
 GO:0016709; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen; IEA:InterPro.
 GO:0006744; P:ubiquinone biosynthetic process; TAS:Reactome. 

Interpro

 IPR002938; mOase_FAD-bd.
 IPR003042; Rng_hydrolase-like.
 IPR018168; Ubi_Hdrlase_CS.
 IPR010971; Ubi_Hdrxlases.
 IPR000689; UbQ_biosynth_mOase. 

Pfam

 PF01494; FAD_binding_3 

SMART

  

PROSITE

 PS01304; UBIH 

PRINTS

 PR00420; RNGMNOXGNASE.