CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005678
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 5-hydroxytryptamine receptor 1B 
Protein Synonyms/Alias
 5-HT-1B; 5-HT1B; Serotonin receptor 1B 
Gene Name
 Htr1b 
Gene Synonyms/Alias
 5ht1b 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
287PVYVNQVKVRVSDALubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. 
Sequence Annotation
 LIPID 384 384 S-palmitoyl cysteine (Potential).
 CARBOHYD 24 24 N-linked (GlcNAc...) (Potential).
 CARBOHYD 28 28 N-linked (GlcNAc...) (Potential).
 DISULFID 118 195 By similarity.  
Keyword
 Cell membrane; Complete proteome; Disulfide bond; G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; Palmitate; Phosphoprotein; Receptor; Reference proteome; Transducer; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 386 AA 
Protein Sequence
MEEQGIQCAP PPPAASQTGV PLTNLSHNCS ADGYIYQDSI ALPWKVLLVA LLALITLATT 60
LSNAFVIATV YRTRKLHTPA NYLIASLAVT DLLVSILVMP ISTMYTVTGR WTLGQVVCDF 120
WLSSDITCCT ASIMHLCVIA LDRYWAITDA VEYSAKRTPK RAAIMIVLVW VFSISISLPP 180
FFWRQAKAEE EMLDCFVNTD HVLYTVYSTV GAFYLPTLLL IALYGRIYVE ARSRILKQTP 240
NKTGKRLTRA QLITDSPGST SSVTSINSRA PDVPSESGSP VYVNQVKVRV SDALLEKKKL 300
MAARERKATK TLGIILGAFI VCWLPFFIIS LVMPICKDAC WFHMAIFDFF NWLGYLNSLI 360
NPIIYTMSNE DFKQAFHKLI RFKCAG 386 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005887; C:integral to plasma membrane; IEA:InterPro.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0008144; F:drug binding; IDA:UniProtKB.
 GO:0051378; F:serotonin binding; IDA:UniProtKB.
 GO:0004993; F:serotonin receptor activity; IDA:UniProtKB.
 GO:0046849; P:bone remodeling; IGI:MGI.
 GO:0071502; P:cellular response to temperature stimulus; IDA:UniProtKB.
 GO:0042756; P:drinking behavior; IEA:Compara.
 GO:0002031; P:G-protein coupled receptor internalization; IDA:UniProtKB.
 GO:0030818; P:negative regulation of cAMP biosynthetic process; IEA:Compara.
 GO:0032229; P:negative regulation of synaptic transmission, GABAergic; IEA:Compara.
 GO:0051967; P:negative regulation of synaptic transmission, glutamatergic; IEA:Compara.
 GO:0007205; P:protein kinase C-activating G-protein coupled receptor signaling pathway; IMP:UniProtKB.
 GO:0050795; P:regulation of behavior; IEA:InterPro.
 GO:0014059; P:regulation of dopamine secretion; IEA:Compara.
 GO:0042220; P:response to cocaine; IEA:Compara.
 GO:0042493; P:response to drug; IDA:UniProtKB.
 GO:0045471; P:response to ethanol; IEA:Compara.
 GO:0051385; P:response to mineralocorticoid stimulus; IEA:Compara.
 GO:0007268; P:synaptic transmission; IEA:Compara.
 GO:0042310; P:vasoconstriction; IEA:InterPro. 
Interpro
 IPR002147; 5HT1B_rcpt.
 IPR002231; 5HT_rcpt.
 IPR000276; GPCR_Rhodpsn.
 IPR017452; GPCR_Rhodpsn_7TM. 
Pfam
 PF00001; 7tm_1 
SMART
  
PROSITE
 PS00237; G_PROTEIN_RECEP_F1_1
 PS50262; G_PROTEIN_RECEP_F1_2 
PRINTS
 PR00513; 5HT1BRECEPTR.
 PR01101; 5HTRECEPTOR.
 PR00237; GPCRRHODOPSN.