UniProt Accession

 KBRS2_HUMAN; Q9NYR9; A6NCZ5; B3KNN0; B4DNM3; Q6PK52; Q96KC7; Q9NSX1 

Genbank Protein ID

 AF229840; AK027265; AK054571; AK297975; DB126967; AL137682; DQ314882; AC105024; CH471152; BC007450; BC063498 

Genbank Nucleotide ID

 AAF34999.1; BAB55006.1; BAG51392.1; BAG60285.1; CAB70873.2; ABC40741.1; EAW60791.1; AAH07450.1; AAH63498.1 

Protein Name

 NF-kappa-B inhibitor-interacting Ras-like protein 2 

Protein Synonyms/Alias

 I-kappa-B-interacting Ras-like protein 2; Kappa B-Ras protein 2; KappaB-Ras2 

Gene Name

 NKIRAS2 

Gene Synonyms/Alias

 KBRAS2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
121	TIVVLGNKCDLQEQR	ubiquitination	[1]
140	DVAQHWAKSEKVKLW	ubiquitination	[1]
167	PFVYLASKMTQPQSK	ubiquitination	[1]
174	KMTQPQSKSAFPLSR	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF- kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity). 

Sequence Annotation

 NP_BIND 11 18 GTP (By similarity).
 NP_BIND 61 65 GTP (By similarity).
 NP_BIND 120 123 GTP (By similarity).
 REGION 1 191 Small GTPase-like.
 MOTIF 35 43 Effector region.  

Keyword

 Alternative splicing; Complete proteome; Cytoplasm; GTP-binding; Nucleotide-binding; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 191 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0016020; C:membrane; IEA:InterPro.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; NAS:UniProtKB.
 GO:0007249; P:I-kappaB kinase/NF-kappaB cascade; NAS:UniProtKB.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR020849; Small_GTPase_Ras. 

Pfam

 PF00071; Ras 

SMART

  

PROSITE

 PS51419; RAB 

PRINTS

 PR00449; RASTRNSFRMNG.