CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001531
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Snurportin-1 
Protein Synonyms/Alias
 RNA U transporter 1 
Gene Name
 SNUPN 
Gene Synonyms/Alias
 RNUT1; SPN1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
228KTKLNPFKFVGLKNFubiquitination[1]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
 Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs. 
Sequence Annotation
 DOMAIN 11 73 IBB.
 REGION 1 159 Necessary for interaction with XPO1.
 REGION 1 65 Necessary for interaction with KPNB1 and
 REGION 208 328 Necessary for binding to the m3G-cap
 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 75 75 Phosphoserine.  
Keyword
 3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleus; Phosphoprotein; Reference proteome; RNA-binding; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 360 AA 
Protein Sequence
MEELSQALAS SFSVSQDLNS TAAPHPRLSQ YKSKYSSLEQ SERRRRLLEL QKSKRLDYVN 60
HARRLAEDDW TGMESEEENK KDDEEMDIDT VKKLPKHYAN QLMLSEWLID VPSDLGQEWI 120
VVVCPVGKRA LIVASRGSTS AYTKSGYCVN RFSSLLPGGN RRNSTAKDYT ILDCIYNEVN 180
QTYYVLDVMC WRGHPFYDCQ TDFRFYWMHS KLPEEEGLGE KTKLNPFKFV GLKNFPCTPE 240
SLCDVLSMDF PFEVDGLLFY HKQTHYSPGS TPLVGWLRPY MVSDVLGVAV PAGPLTTKPD 300
YAGHQLQQIM EHKKSQKEGM KEKLTHKASE NGHYELEHLS TPKLKGSSHS PDHPGCLMEN 360 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005643; C:nuclear pore; TAS:ProtInc.
 GO:0008565; F:protein transporter activity; IEA:InterPro.
 GO:0000339; F:RNA cap binding; TAS:ProtInc.
 GO:0034660; P:ncRNA metabolic process; TAS:Reactome.
 GO:0006606; P:protein import into nucleus; IEA:InterPro.
 GO:0061015; P:snRNA import into nucleus; IEA:InterPro.
 GO:0000387; P:spliceosomal snRNP assembly; TAS:Reactome. 
Interpro
 IPR002652; Importin-a_IBB.
 IPR017336; Snurportin-1.
 IPR024721; Snurportin-1_N. 
Pfam
 PF11538; Snurportin1 
SMART
  
PROSITE
 PS51214; IBB 
PRINTS