UniProt Accession

 TR10D_HUMAN; Q9UBN6; B2R8W0; Q9Y6Q4 

Genbank Protein ID

 AF029761; AF021232; AF021233; AF023849; AY358285; AK313528; BC052270 

Genbank Nucleotide ID

 AAD03477.1; AAC32765.1; AAC32766.1; AAC52053.1; AAQ88652.1; BAG36307.1; AAH52270.1 

Protein Name

 Tumor necrosis factor receptor superfamily member 10D 

Protein Synonyms/Alias

 Decoy receptor 2; DcR2; TNF-related apoptosis-inducing ligand receptor 4; TRAIL receptor 4; TRAIL-R4; TRAIL receptor with a truncated death domain; CD264 

Gene Name

 TNFRSF10D 

Gene Synonyms/Alias

 DCR2; TRAILR4; TRUNDD; UNQ251/PRO288 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
241	KKFISYLKGICSGGG	ubiquitination	[1, 2, 3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF- kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway. 

Sequence Annotation

 REPEAT 58 97 TNFR-Cys 1.
 REPEAT 98 139 TNFR-Cys 2.
 REPEAT 140 180 TNFR-Cys 3.
 DOMAIN 340 366 Death; truncated.
 CARBOHYD 127 127 N-linked (GlcNAc...) (Potential).
 CARBOHYD 182 182 N-linked (GlcNAc...) (Potential).
 DISULFID 83 96 By similarity.
 DISULFID 99 115 By similarity.
 DISULFID 118 131 By similarity.
 DISULFID 121 139 By similarity.
 DISULFID 141 155 By similarity.
 DISULFID 158 172 By similarity.
 DISULFID 162 180 By similarity.  

Keyword

 Apoptosis; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Membrane; Polymorphism; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 386 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0004888; F:transmembrane signaling receptor activity; TAS:ProtInc.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0043066; P:negative regulation of apoptotic process; TAS:ProtInc. 

Interpro

 IPR001368; TNFR/NGFR_Cys_rich_reg.
 IPR020465; TNFR_10. 

Pfam

 PF00020; TNFR_c6 

SMART

 SM00208; TNFR 

PROSITE

 PS50017; DEATH_DOMAIN
 PS00652; TNFR_NGFR_1
 PS50050; TNFR_NGFR_2 

PRINTS

 PR01956; TNFACTORR10.