CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001824
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Anthranilate synthase component 1 
Protein Synonyms/Alias
 Anthranilate synthase component I 
Gene Name
 trpE 
Gene Synonyms/Alias
 b1264; JW1256 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
46ESADIDSKDDLKSLLacetylation[1]
50IDSKDDLKSLLLVDSacetylation[1]
138QNLLNVPKEEREAMFacetylation[1]
205FAPNEEEKQRLTARLacetylation[1]
254GVVRLLQKAIRAGEIacetylation[1]
357LEMRTDHKELSEHLMacetylation[1]
389RYVADLTKVDRYSYVacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
  
Sequence Annotation
  
Keyword
 Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Complete proteome; Direct protein sequencing; Lyase; Reference proteome; Tryptophan biosynthesis. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 520 AA 
Protein Sequence
MQTQKPTLEL LTCEGAYRDN PTALFHQLCG DRPATLLLES ADIDSKDDLK SLLLVDSALR 60
ITALGDTVTI QALSGNGEAL LALLDNALPA GVESEQSPNC RVLRFPPVSP LLDEDARLCS 120
LSVFDAFRLL QNLLNVPKEE REAMFFGGLF SYDLVAGFED LPQLSAENNC PDFCFYLAET 180
LMVIDHQKKS TRIQASLFAP NEEEKQRLTA RLNELRQQLT EAAPPLPVVS VPHMRCECNQ 240
SDEEFGGVVR LLQKAIRAGE IFQVVPSRRF SLPCPSPLAA YYVLKKSNPS PYMFFMQDND 300
FTLFGASPES SLKYDATSRQ IEIYPIAGTR PRGRRADGSL DRDLDSRIEL EMRTDHKELS 360
EHLMLVDLAR NDLARICTPG SRYVADLTKV DRYSYVMHLV SRVVGELRHD LDALHAYRAC 420
MNMGTLSGAP KVRAMQLIAE AEGRRRGSYG GAVGYFTAHG DLDTCIVIRS ALVENGIATV 480
QAGAGVVLDS VPQSEADETR NKARAVLRAI ATAHHAQETF 520 
Gene Ontology
 GO:0004049; F:anthranilate synthase activity; IDA:EcoCyc.
 GO:0000162; P:tryptophan biosynthetic process; IDA:EcoCyc. 
Interpro
 IPR005801; ADC_synthase.
 IPR019999; Anth_synth_I.
 IPR006805; Anth_synth_I_N.
 IPR005257; Anth_synth_I_TrpE.
 IPR015890; Chorismate-bd_C. 
Pfam
 PF04715; Anth_synt_I_N
 PF00425; Chorismate_bind 
SMART
  
PROSITE
  
PRINTS
 PR00095; ANTSNTHASEI.