UniProt Accession

 SYPH_HUMAN; P08247; B2R7L6; Q6P2F7 

Genbank Protein ID

 X06389; U93305; AK313030; CH471224; BC064550 

Genbank Nucleotide ID

 CAA29686.1; AAB92358.1; BAG35863.1; EAW50685.1; AAH64550.1 

Protein Name

 Synaptophysin 

Protein Synonyms/Alias

 Major synaptic vesicle protein p38 

Gene Name

 SYP 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
168	AKGLSDVKMATDPEN	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity (By similarity). 

Sequence Annotation

 DOMAIN 21 227 MARVEL.
 REGION 254 305 Repeats, Gly-rich.
 MOD_RES 81 81 Phosphotyrosine (By similarity).
 CARBOHYD 59 59 N-linked (GlcNAc...) (Potential).  

Keyword

 Calcium; Cell junction; Complete proteome; Cytoplasmic vesicle; Disease mutation; Glycoprotein; Membrane; Mental retardation; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Synapse; Synaptosome; Transmembrane; Transmembrane helix; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 313 AA 

Protein Sequence

Gene Ontology

 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0060076; C:excitatory synapse; IEA:Compara.
 GO:0030285; C:integral to synaptic vesicle membrane; NAS:UniProtKB.
 GO:0044306; C:neuron projection terminus; IEA:Compara.
 GO:0048786; C:presynaptic active zone; IEA:Compara.
 GO:0042734; C:presynaptic membrane; IEA:Compara.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0005509; F:calcium ion binding; NAS:UniProtKB.
 GO:0015485; F:cholesterol binding; IDA:UniProtKB.
 GO:0005215; F:transporter activity; IEA:InterPro.
 GO:0071310; P:cellular response to organic substance; IEA:Compara.
 GO:0048169; P:regulation of long-term neuronal synaptic plasticity; ISS:UniProtKB.
 GO:2000474; P:regulation of opioid receptor signaling pathway; ISS:UniProtKB.
 GO:0048172; P:regulation of short-term neuronal synaptic plasticity; ISS:UniProtKB.
 GO:0016188; P:synaptic vesicle maturation; NAS:UniProtKB.
 GO:0048499; P:synaptic vesicle membrane organization; NAS:UniProtKB. 

Interpro

 IPR008253; Marvel.
 IPR021128; MARVEL-like_dom.
 IPR001285; Synaptophysin/porin. 

Pfam

 PF01284; MARVEL 

SMART

  

PROSITE

 PS51225; MARVEL
 PS00604; SYNAPTOP 

PRINTS

 PR00220; SYNAPTOPHYSN.