CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007148
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein IFH1 
Protein Synonyms/Alias
 Ribosomal RNA-processing protein 3 
Gene Name
 IFH1 
Gene Synonyms/Alias
 RRP3; YLR223C; L8083.9 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
9AGKKSPRKSTINHSTacetylation[1]
20NHSTHSGKLPANIKRacetylation[1]
180QRKKRAMKALSAMNTacetylation[1]
254TQQALSFKFKKEDDGacetylation[1]
725GTWETDNKPFSIIDGubiquitination[2]
736IIDGLSTKSLYALIQubiquitination[2]
821ADWYEVPKVPLSAFRubiquitination[2]
830PLSAFRNKGINAYEEubiquitination[2]
849IPANSNRKVPIGYIGubiquitination[2]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Controls the pre-rRNA processing machinery in conjunction with FHL1. Could convert FHL1 from a repressor to an activator. 
Sequence Annotation
 MOD_RES 208 208 Phosphoserine.
 MOD_RES 1041 1041 Phosphoserine.  
Keyword
 Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1085 AA 
Protein Sequence
MAGKKSPRKS TINHSTHSGK LPANIKRLIK KGESDTKSRQ SPPTLSTTRP RRFSLIYSSE 60
SSLSDVSDSD KNKSTNPHKI KRKAKNISNN SQGKKSKLIQ RQIDNDDEGT ESSDYQAVTD 120
GEESENEEEE SEEEEEDDDE DDDDDDDDGS DSDSDSETSS DDENIDFVKL TAQRKKRAMK 180
ALSAMNTNSN TLYSSRENSN KNKSVKLSPK KENEEEQKEE KEKEKEEQQK QQESNKKEVN 240
GSGTTTTQQA LSFKFKKEDD GISFGNGNEG YNEDIGEEVL DLKNKENNGN EEDKLDSKVM 300
LGNNDELRFP NISESDESEY DIDQDAYFDV INNEDSHGEI GTDLETGEDD LPILEEEEQN 360
IVSELQNDDE LSFDGSIHEE GSDPVEDAEN KFLQNEYNQE NGYDEEDDEE DEIMSDFDMP 420
FYEDPKFANL YYYGDGSEPK LSLSTSLPLM LNDEKLSKLK KKEAKKREQE ERKQRRKLYK 480
KTQKPSTRTT SNVDNDEYIF NVFFQSDDEN SGHKSKKGRH KSGKSHIEHK NKGSNLIKSN 540
DDLEPSTHST VLNSGKYDSS DDEYDNILLD VAHMPSDDEC SESETSHDAD TDEELRALDS 600
DSLDIGTELD DDYEDDDDDS SVTNVFIDID DLDPDSFYFH YDSDGSSSLI SSNSDKENSD 660
GSKDCKHDLL ETVVYVDDES TDEDDNLPPP SSRSKNIGSK AKEIVSSNVV GLRPPKLGTW 720
ETDNKPFSII DGLSTKSLYA LIQEHQQLRE QHQRAQTPDV KREGSSNGNN GDELTLNELL 780
NMSELEDDSP SHTDDMENNY NDAINSKSTN GHAADWYEVP KVPLSAFRNK GINAYEEDEY 840
MIPANSNRKV PIGYIGNERT RKKIDKMKEL QRKKTEKKRQ LKKKKKLLKI RKQRQKAIKE 900
QETMNLQLGI NGHEIIGNNN SHSDINTGTD FTTNENTPMN ELPSHAPEDA SLIPHNSDLA 960
VDSNTRKNST KSVGLDEIHE ILGKDENDLL SVGDINGYDA QEGHVIEDTD ADILASLTAP 1020
VQFDNTLSHE NSNSMWRRRQ SMVEAAAENL RFTKNGLFSE SALADIEGIM GNDVNHSFEF 1080
NDVLQ 1085 
Gene Ontology
 GO:0032545; C:CURI complex; IDA:SGD.
 GO:0000790; C:nuclear chromatin; IDA:SGD.
 GO:0005730; C:nucleolus; IDA:SGD.
 GO:0003713; F:transcription coactivator activity; IMP:SGD.
 GO:0006348; P:chromatin silencing at telomere; IMP:SGD.
 GO:0060963; P:positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter; IMP:SGD.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR018837; TF_CRF1. 
Pfam
 PF10380; CRF1 
SMART
  
PROSITE
  
PRINTS