UniProt Accession

 VDAC3_RAT; Q9R1Z0; Q6GSZ1; Q9ESR2; Q9JI31; Q9WTU2 

Genbank Protein ID

 AB039664; AF268469; BC061780; AF048829; AF048830 

Genbank Nucleotide ID

 BAB13475.1; AAF80117.1; AAH61780.1; AAD22722.1; AAD22723.1 

Protein Name

 Voltage-dependent anion-selective channel protein 3 

Protein Synonyms/Alias

 VDAC-3; rVDAC3; Outer mitochondrial membrane protein porin 3 

Gene Name

 Vdac3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
12	PTYCDLGKAAKDVFN	acetylation	[1]
15	CDLGKAAKDVFNKGY	acetylation	[1]
15	CDLGKAAKDVFNKGY	ubiquitination	[2]
20	AAKDVFNKGYGFGMV	acetylation	[1]
20	AAKDVFNKGYGFGMV	ubiquitination	[2]
61	ASGNLETKYKVCNYG	acetylation	[1]
63	GNLETKYKVCNYGLI	acetylation	[1]
90	TEISWENKLAEGLKL	acetylation	[1]
96	NKLAEGLKLTVDTIF	acetylation	[1]
109	IFVPNTGKKSGKLKA	acetylation	[1]
109	IFVPNTGKKSGKLKA	ubiquitination	[2]
163	SFDTAKSKLCQNNFA	acetylation	[1]
174	NNFALGYKAEDFQLH	acetylation	[1]
224	TRFGIAAKYRLDCRT	acetylation	[1]
236	CRTSLSAKVNNASLI	acetylation	[1]
266	LSALVDGKNFNAGGH	acetylation	[1]
274	NFNAGGHKVGLGFEL	ubiquitination	[2]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules (By similarity). 

Sequence Annotation

 NP_BIND 242 244 NAD (By similarity).
 NP_BIND 260 264 NAD (By similarity).
 MOD_RES 2 2 N-acetylcysteine (By similarity).
 MOD_RES 20 20 N6-acetyllysine (By similarity).
 MOD_RES 33 33 Phosphothreonine.
 MOD_RES 48 48 Phosphotyrosine (By similarity).
 MOD_RES 90 90 N6-acetyllysine (By similarity).
 MOD_RES 241 241 Phosphoserine.  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Ion transport; Membrane; Mitochondrion; Mitochondrion outer membrane; NAD; Nucleotide-binding; Phosphoprotein; Porin; Reference proteome; Transmembrane; Transmembrane beta strand; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 283 AA 

Protein Sequence

Gene Ontology

 GO:0005741; C:mitochondrial outer membrane; TAS:RGD.
 GO:0046930; C:pore complex; IEA:UniProtKB-KW.
 GO:0005791; C:rough endoplasmic reticulum; IDA:RGD.
 GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
 GO:0015288; F:porin activity; IEA:UniProtKB-KW.
 GO:0008308; F:voltage-gated anion channel activity; IEA:InterPro. 

Interpro

 IPR023614; Porin_dom.
 IPR001925; Porin_Euk.
 IPR027246; Porin_Euk/Tom40. 

Pfam

 PF01459; Porin_3 

SMART

  

PROSITE

 PS00558; EUKARYOTIC_PORIN 

PRINTS

 PR00185; EUKARYTPORIN.