| Tag | Content |
|---|
| CPLM ID | CPLM-017345 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein THEMIS |
Protein Synonyms/Alias | Thymocyte-expressed molecule involved in selection |
Gene Name | THEMIS |
Gene Synonyms/Alias | C6orf190; C6orf207 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 92 | LFKIVADKTPYLTME | ubiquitination | [1] | | 124 | FYHQKDIKLENLIIK | ubiquitination | [1] | | 191 | LKEIVEWKIPKNRTR | ubiquitination | [1] | | 208 | NLTDFSNKWDSTNPF | ubiquitination | [1] | | 595 | HHVDITKKLHPNQAG | ubiquitination | [1] |
|
Reference | [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA. Mol Cell Proteomics. 2012 May;11(5):148-59. [ PMID: 22505724] |
Functional Description | Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk (By similarity). |
Sequence Annotation | REGION 1 259 CABIT 1.
REGION 260 518 CABIT 2.
MOD_RES 584 584 Phosphoserine. |
Keyword | Adaptive immunity; Alternative splicing; Complete proteome; Cytoplasm; Developmental protein; Immunity; Nucleus; Phosphoprotein; Polymorphism; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 641 AA |
Protein Sequence | MALSLEEFVH SLDLRTLPRV LEIQAGIYLE GSIYEMFGNE CCFSTGEVIK ITGLKVKKII 60
AEICEQIEGC ESLQPFELPM NFPGLFKIVA DKTPYLTMEE ITRTIHIGPS RLGHPCFYHQ 120
KDIKLENLII KQGEQIMLNS VEEIDGEIMV SCAVARNHQT HSFNLPLSQE GEFYECEDER 180
IYTLKEIVEW KIPKNRTRTV NLTDFSNKWD STNPFPKDFY GTLILKPVYE IQGVMKFRKD 240
IIRILPSLDV EVKDITDSYD ANWFLQLLST EDLFEMTSKE FPIVTEVIEA PEGNHLPQSI 300
LQPGKTIVIH KKYQASRILA SEIRSNFPKR HFLIPTSYKG KFKRRPREFP TAYDLEIAKS 360
EKEPLHVVAT KAFHSPHDKL SSVSVGDQFL VHQSETTEVL CEGIKKVVNV LACEKILKKS 420
YEAALLPLYM EGGFVEVIHD KKQYPISELC KQFRLPFNVK VSVRDLSIEE DVLAATPGLQ 480
LEEDITDSYL LISDFANPTE CWEIPVGRLN MTVQLVSNFS RDAEPFLVRT LVEEITEEQY 540
YMMRRYESSA SHPPPRPPKH PSVEETKLTL LTLAEERTVD LPKSPKRHHV DITKKLHPNQ 600
AGLDSKVLIG SQNDLVDEEK ERSNRGATAI AETFKNEKHQ K 641 |
Gene Ontology | GO:0005737; C:cytoplasm; ISS:UniProtKB. GO:0008180; C:signalosome; ISS:UniProtKB. GO:0043383; P:negative T cell selection; ISS:UniProtKB. GO:0043368; P:positive T cell selection; ISS:UniProtKB. GO:0050852; P:T cell receptor signaling pathway; ISS:UniProtKB. |
Interpro | |
Pfam | |
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PRINTS | |