CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002239
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Heterochromatin protein 1 
Protein Synonyms/Alias
 HP1; Non-histone chromosomal protein C1A9 antigen 
Gene Name
 Su(var)205 
Gene Synonyms/Alias
 HP1; CG8409 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
38DRRVRKGKVEYYLKWacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 Structural component of heterochromatin, involved in gene repression and the modification of position-effect- variegation. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. 
Sequence Annotation
 DOMAIN 24 82 Chromo 1.
 DOMAIN 147 205 Chromo 2.
 REGION 95 206 Binds to Su(var)39.
 BINDING 24 24 Histone H3K9me2.
 BINDING 45 45 Histone H3K9me2.
 BINDING 48 48 Histone H3K9me2.
 MOD_RES 11 11 Phosphoserine.
 MOD_RES 15 15 Phosphoserine.
 MOD_RES 102 102 Phosphoserine.
 MOD_RES 103 103 Phosphoserine.
 MOD_RES 113 113 Phosphoserine.
 MOD_RES 127 127 Phosphothreonine.
 MOD_RES 128 128 Phosphothreonine.
 MOD_RES 134 134 Phosphothreonine.  
Keyword
 3D-structure; Chromatin regulator; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 206 AA 
Protein Sequence
MGKKIDNPES SAKVSDAEEE EEEYAVEKII DRRVRKGKVE YYLKWKGYPE TENTWEPENN 60
LDCQDLIQQY EASRKDEEKS AASKKDRPSS SAKAKETQGR ASSSTSTASK RKSEEPTAPS 120
GNKSKRTTDA EQDTIPVSGS TGFDRGLEAE KILGASDNNG RLTFLIQFKG VDQAEMVPSS 180
VANEKIPRMV IHFYEERLSW YSDNED 206 
Gene Ontology
 GO:0005721; C:centromeric heterochromatin; NAS:FlyBase.
 GO:0000780; C:condensed nuclear chromosome, centromeric region; IDA:FlyBase.
 GO:0005720; C:nuclear heterochromatin; IDA:FlyBase.
 GO:0005704; C:polytene chromosome band; IDA:FlyBase.
 GO:0005701; C:polytene chromosome chromocenter; IDA:FlyBase.
 GO:0005703; C:polytene chromosome puff; IDA:FlyBase.
 GO:0035012; C:polytene chromosome, telomeric region; IDA:FlyBase.
 GO:0003682; F:chromatin binding; IDA:FlyBase.
 GO:0042393; F:histone binding; NAS:FlyBase.
 GO:0003729; F:mRNA binding; NAS:FlyBase.
 GO:0000182; F:rDNA binding; IDA:FlyBase.
 GO:0003696; F:satellite DNA binding; IDA:FlyBase.
 GO:0030702; P:chromatin silencing at centromere; IMP:FlyBase.
 GO:0044026; P:DNA hypermethylation; IMP:FlyBase.
 GO:0006343; P:establishment of chromatin silencing; IMP:FlyBase.
 GO:0034773; P:histone H4-K20 trimethylation; IMP:FlyBase.
 GO:0022008; P:neurogenesis; IMP:FlyBase.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; TAS:FlyBase.
 GO:0042981; P:regulation of apoptotic process; IMP:FlyBase.
 GO:0031060; P:regulation of histone methylation; IMP:FlyBase.
 GO:0000723; P:telomere maintenance; IMP:FlyBase.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR017984; Chromo_dom_subgr.
 IPR023780; Chromo_domain.
 IPR000953; Chromo_domain/shadow.
 IPR008251; Chromo_shadow_dom.
 IPR016197; Chromodomain-like.
 IPR023779; Chromodomain_CS. 
Pfam
 PF00385; Chromo
 PF01393; Chromo_shadow 
SMART
 SM00298; CHROMO
 SM00300; ChSh 
PROSITE
 PS00598; CHROMO_1
 PS50013; CHROMO_2 
PRINTS
 PR00504; CHROMODOMAIN.