UniProt Accession

 RAB18_HUMAN; Q9NP72; B3KMC7; B7Z333; D3DRW1; Q53FX8; Q56UN9; Q6FIH1 

Genbank Protein ID

 AJ277145; AJ277146; AJ277147; AJ277148; AJ277149; AF137372; AY574034; AF087860; AF498950; AF136974; AL136734; BT009840; CR533455; AK001555; AK295443; AK223153; AL138920; CH471072; CH471072; BC015014; BC029350 

Genbank Nucleotide ID

 CAB86486.1; CAB86486.1; CAB86486.1; CAB86486.1; CAB86486.1; AAF61433.1; AAU08232.1; AAP97170.1; AAM21098.1; AAG49435.1; CAB66668.1; AAP88842.1; CAG38486.1; BAG50939.1; BAH12069.1; BAD96873.1; CAH70590.1; EAW86054.1; EAW86055.1; AAH15014.1; AAH29350.1 

Protein Name

 Ras-related protein Rab-18 

Protein Synonyms/Alias

  

Gene Name

 RAB18 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
56	TISVDGNKAKLAIWD	ubiquitination	[1]
123	VNMLVGNKIDKENRE	ubiquitination	[1]
138	VDRNEGLKFARKHSM	acetylation	[2]
138	VDRNEGLKFARKHSM	ubiquitination	[1]
142	EGLKFARKHSMLFIE	ubiquitination	[1]
183	WESENQNKGVKLSHR	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 

Functional Description

 Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes. Plays a key role in eye and brain development and neurodegeneration. 

Sequence Annotation

 NP_BIND 15 23 GTP.
 NP_BIND 63 67 GTP.
 NP_BIND 122 125 GTP.
 NP_BIND 151 153 GTP.
 MOTIF 37 45 Effector region (By similarity).
 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 203 203 Cysteine methyl ester (Potential).
 LIPID 199 199 S-palmitoyl cysteine (Potential).
 LIPID 203 203 S-geranylgeranyl cysteine (By  

Keyword

 3D-structure; Acetylation; Alternative splicing; Cell membrane; Complete proteome; Developmental protein; Direct protein sequencing; GTP-binding; Lipoprotein; Membrane; Methylation; Nucleotide-binding; Palmitate; Polymorphism; Prenylation; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 206 AA 

Protein Sequence

Gene Ontology

 GO:0005622; C:intracellular; IDA:LIFEdb.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0019003; F:GDP binding; IDA:UniProtKB.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; NAS:UniProtKB.
 GO:0007420; P:brain development; ISS:UniProtKB.
 GO:0006897; P:endocytosis; NAS:UniProtKB.
 GO:0001654; P:eye development; ISS:UniProtKB.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0007264; P:small GTPase mediated signal transduction; NAS:UniProtKB. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR025662; Sigma_54_int_dom_ATP-bd_1.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003579; Small_GTPase_Rab_type. 

Pfam

 PF00071; Ras 

SMART

 SM00175; RAB 

PROSITE

 PS51419; RAB 

PRINTS

 PR00449; RASTRNSFRMNG.