CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042770
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 RUN and FYVE domain-containing protein 2 
Protein Synonyms/Alias
  
Gene Name
 RUFY2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
18ARTGPATKDPTAVERubiquitination[1, 2]
Reference
 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 620 AA 
Protein Sequence
XGLEVPRRPG ARTGPATKDP TAVERANLLN MAKLSIKGLI ESALSFGRTL DSDYPPLQQF 60
FVVMEHCLKH GLKVRKSFLS YNKTIWGPLE LVEKLYPEAE EIGASVRDLP GLKTPLGRAR 120
AWLRLALMQK KMADYLRCLI IQRDLLSEFY EYHALMMEEE GAVIVGLLVG LNVIDANLCV 180
KGEDLDSQVG VIDFSMYLKN EEDIGNKERN VQIAAILDQK NYVEELNRQL NSTVSSLHSR 240
VDSLEKSNTK LIEELAIAKN NIIKLQEENH QLRSENKLIL MKTQQHLEVT KVDVETELQT 300
YKHSRQGLDE MYNEARRQLR DESQLRQDVE NELAVQVSMK HEIELAMKLL EKDIHEKQDT 360
LIGLRQQLEE VKAINIEMYQ KLQGSEDGLK EKNEIIARLE EKTNKITAAM RQLEQRLQQA 420
EKAQMEAEDE DEKYLQECLS KSDSLQKQIS QKEKQLVQLE TDLKIEKEWR QTLQEDLQKE 480
KDALSHLRNE TQQIISLKKE FLNLQDENQQ LKKIYHEQEQ ALQELGNKLS ESKLKIEDIK 540
EANKALQGLV WLKDKEATHC KLCEKEFSLS KRKHHCRNCG EIFCNACSDN ELPLPSSPKP 600
VRVCDSCHAL LIQRCSSNLP 620 
Gene Ontology
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. 
Interpro
 IPR004012; Run.
 IPR000306; Znf_FYVE.
 IPR017455; Znf_FYVE-rel.
 IPR011011; Znf_FYVE_PHD.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF01363; FYVE
 PF02759; RUN 
SMART
 SM00064; FYVE
 SM00593; RUN 
PROSITE
 PS50826; RUN
 PS50178; ZF_FYVE 
PRINTS