CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041743
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Aldehyde dehydrogenase family 5, subfamily A1 
Protein Synonyms/Alias
 Succinate-semialdehyde dehydrogenase, mitochondrial 
Gene Name
 Aldh5a1 
Gene Synonyms/Alias
 rCG_45159 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
106SWKEISVKERSSLLRacetylation[1]
114ERSSLLRKWYDLMIQacetylation[1]
123YDLMIQNKDELAKIIacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 523 AA 
Protein Sequence
MATCFLLRNF CAARPALRPP GRLLREPAGA QRRSYVGGPA DLHADLLRGD SFVGGRWLPT 60
PATFPVYDPA SGAKLGTVAD CGVPEARAAV RAAYDAFSSW KEISVKERSS LLRKWYDLMI 120
QNKDELAKII TAESGKPLKE AQGEILYSAF FLEWFSEEAR RVYGDIIYTS AKDKRGLVLK 180
QPVGVASIIT PWNFPSAMIT RKVGAALAAG CTVVVKPAED TPYSALALAQ LANQAGIPPG 240
VYNVIPCSRT KAKEVGEVLC TDPLVSKISF TGSTATGKIL LHHAANSVKR VSMELGGLAP 300
FIVFDSANVD QAVAGAMASK FRNAGQTCVC SNRFLVQRGI HDSFVTKFAE AMKKSLRVGN 360
GFEEGTTQGP LINEKAVEKV EKHVNDAVAK GATVVTGGKR HQSGGNFFEP TLLSNVTRDM 420
LCITEETFGP LAPVIKFDKE EEAVAIANAA DVGLAGYFYS QDPAQIWRVA EQLEVGMVGV 480
NEGLISSVEC PFGGVKQSGL GREGSKYGID EYLEVKYVCY GGL 523 
Gene Ontology
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0009013; F:succinate-semialdehyde dehydrogenase [NAD(P)+] activity; IEA:InterPro.
 GO:0006083; P:acetate metabolic process; IEA:Compara.
 GO:0007417; P:central nervous system development; IEA:Compara.
 GO:0006681; P:galactosylceramide metabolic process; IEA:Compara.
 GO:0009450; P:gamma-aminobutyric acid catabolic process; IEA:InterPro.
 GO:0006006; P:glucose metabolic process; IEA:Compara.
 GO:0006678; P:glucosylceramide metabolic process; IEA:Compara.
 GO:0006536; P:glutamate metabolic process; IEA:Compara.
 GO:0006541; P:glutamine metabolic process; IEA:Compara.
 GO:0006749; P:glutathione metabolic process; IEA:Compara.
 GO:0006650; P:glycerophospholipid metabolic process; IEA:Compara.
 GO:0042135; P:neurotransmitter catabolic process; IEA:Compara.
 GO:0009791; P:post-embryonic development; IEA:Compara.
 GO:0051289; P:protein homotetramerization; IEA:Compara.
 GO:0022904; P:respiratory electron transport chain; IEA:Compara.
 GO:0046459; P:short-chain fatty acid metabolic process; IEA:Compara.
 GO:0006105; P:succinate metabolic process; IEA:Compara. 
Interpro
 IPR016161; Ald_DH/histidinol_DH.
 IPR016163; Ald_DH_C.
 IPR016160; Ald_DH_CS.
 IPR016162; Ald_DH_N.
 IPR015590; Aldehyde_DH_dom.
 IPR010102; Succ_semiAld_DH. 
Pfam
 PF00171; Aldedh 
SMART
  
PROSITE
 PS00070; ALDEHYDE_DEHYDR_CYS
 PS00687; ALDEHYDE_DEHYDR_GLU 
PRINTS