CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034215
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein arginine N-methyltransferase 1 
Protein Synonyms/Alias
  
Gene Name
 Prmt1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
60AAKAGARKVIGIECSacetylation[1]
78DYAVKIVKANKLDHVubiquitination[2]
81VKIVKANKLDHVVTIacetylation[1, 3]
81VKIVKANKLDHVVTIsuccinylation[3]
81VKIVKANKLDHVVTIubiquitination[2]
92VVTIIKGKVEEVELPacetylation[4]
130TVLHARDKWLAPDGLacetylation[1]
180CIKDVAIKEPLVDVVubiquitination[2]
289IGMRPNAKNNRDLDFubiquitination[2]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Methyltransferase; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 318 AA 
Protein Sequence
MAAAEAANCI MEMLKDEVRT LTYRNSMFHN RHLFKDKVVL DVGSGTGILC MFAAKAGARK 60
VIGIECSSIS DYAVKIVKAN KLDHVVTIIK GKVEEVELPV EKVDIIISEW MGYCLFYESM 120
LNTVLHARDK WLAPDGLIFP DRATLYVTAI EDRQYKDYKI HWWENVYGFD MSCIKDVAIK 180
EPLVDVVDPK QLVTNACLIK EVDIYTVKVE DLTFTSPFCL QVKRNDYVHA LVAYFNIEFT 240
RCHKRTGFST SPESPYTHWK QTVFYMEDYL TVKTGEEIFG TIGMRPNAKN NRDLDFTIDL 300
DFKGQLCELS CSTDYRMR 318 
Gene Ontology
 GO:0016274; F:protein-arginine N-methyltransferase activity; IDA:MGI.
 GO:0001701; P:in utero embryonic development; IMP:MGI. 
Interpro
 IPR025799; Arg_MeTrfase.
 IPR025714; Methyltranfer_dom. 
Pfam
 PF13847; Methyltransf_31 
SMART
  
PROSITE
  
PRINTS