UniProt Accession

 PTHP_MYCPN; P75061 

Genbank Protein ID

 U00089 

Genbank Nucleotide ID

 AAB95749.1 

Protein Name

 Phosphocarrier protein HPr 

Protein Synonyms/Alias

 Histidine-containing protein 

Gene Name

 ptsH 

Gene Synonyms/Alias

 MPN_053; MP101 

Created Date

 July 27, 2013 

Organism

 Mycoplasma pneumoniae (strain ATCC 29342 / M129) 

NCBI Taxa ID

 272634 

Lysine Modification

Position	Peptide	Type	References
30	AGEANKFKSELKLVS	acetylation	[1]
65	QNDHITIKAEGTDEE	acetylation	[1]
84	AIKAVLEKHQVI***	acetylation	[1]

Reference

 [1] Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium.
 van Noort V, Seebacher J, Bader S, Mohammed S, Vonkova I, Betts MJ, Kühner S, Kumar R, Maier T, O'Flaherty M, Rybin V, Schmeisky A, Yus E, Stülke J, Serrano L, Russell RB, Heck AJ, Bork P, Gavin AC.
 Mol Syst Biol. 2012 Feb 28;8:571. [PMID: 22373819] 

Functional Description

 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the permease (enzymes II/III). 

Sequence Annotation

 DOMAIN 1 88 HPr.
 ACT_SITE 15 15 Pros-phosphohistidine intermediate (By
 MOD_RES 47 47 Phosphoserine; by HPrK/P.  

Keyword

 Complete proteome; Cytoplasm; Direct protein sequencing; Kinase; Phosphoprotein; Phosphotransferase system; Reference proteome; Serine/threonine-protein kinase; Sugar transport; Transcription; Transcription regulation; Transferase; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 88 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
 GO:0005351; F:sugar:hydrogen symporter activity; IEA:InterPro.
 GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR001020; PTS_HPr_His_P_site.
 IPR005698; PTS_HPr_prot.
 IPR000032; PTS_HPr_prot-like.
 IPR002114; PTS_HPr_Ser_P_site. 

Pfam

 PF00381; PTS-HPr 

SMART

  

PROSITE

 PS51350; PTS_HPR_DOM
 PS00369; PTS_HPR_HIS
 PS00589; PTS_HPR_SER 

PRINTS

 PR00107; PHOSPHOCPHPR.