CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013565
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Delta(24)-sterol reductase 
Protein Synonyms/Alias
 24-dehydrocholesterol reductase; 3-beta-hydroxysterol delta-24-reductase 
Gene Name
 Dhcr24 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
313KHVENYLKTNREGLEubiquitination[1]
492FDGSLYHKLRKQLGCubiquitination[1]
495SLYHKLRKQLGCQDAubiquitination[1]
509AFPEVYDKICKAARHubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Catalyzes the reduction of the delta-24 double bond of sterol intermediates (By similarity). 
Sequence Annotation
 DOMAIN 58 234 FAD-binding PCMH-type.
 NP_BIND 163 175 FAD (Potential).  
Keyword
 Cholesterol biosynthesis; Cholesterol metabolism; Complete proteome; Endoplasmic reticulum; FAD; Golgi apparatus; Lipid biosynthesis; Lipid metabolism; Membrane; NADP; Oxidoreductase; Reference proteome; Signal; Steroid biosynthesis; Steroid metabolism; Sterol biosynthesis; Sterol metabolism; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 516 AA 
Protein Sequence
MEPAVSLAVC ALLFLLWVRV KGLEFVLIHQ RWVFVCLFLL PLSLIFDIYY YVRAWVVFKL 60
SSAPRLHEQR VQDIQKQVRE WKEQGSKTFM CTGRPGWLTV SLRVGKYKKT HKNIMINLMD 120
ILEVDTKKQI VRVEPLVSMG QVTALLNSIG WTLPVLPELD DLTVGGLIMG TGIESSSHKY 180
GLFQHICTAY ELILADGSFV RCTPSENSDL FYAVPWSCGT LGFLVAAEIR IIPAKKYVKL 240
RFEPVRGLEA ICEKFTHESQ RLENHFVEGL LYSLDEAVIM TGVMTDDVEP SKLNSIGSYY 300
KPWFFKHVEN YLKTNREGLE YIPLRHYYHR HTRSIFWELQ DIIPFGNNPI FRYLFGWMVP 360
PKISLLKLTQ GETLRKLYEQ HHVVQDMLVP MKCLSQALHT FQNDIHVYPI WLCPFILPSQ 420
PGLVHPKGDE AELYVDIGAY GEPRVKHFEA RSCMRQLEKF VRSVHGFQML YADCYMNREE 480
FWEMFDGSLY HKLRKQLGCQ DAFPEVYDKI CKAARH 516 
Gene Ontology
 GO:0005856; C:cytoskeleton; IDA:RGD.
 GO:0005829; C:cytosol; IDA:RGD.
 GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0016020; C:membrane; IDA:RGD.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0050614; F:delta24-sterol reductase activity; IC:RGD.
 GO:0019899; F:enzyme binding; ISS:UniProtKB.
 GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
 GO:0042605; F:peptide antigen binding; ISS:UniProtKB.
 GO:0008762; F:UDP-N-acetylmuramate dehydrogenase activity; IEA:InterPro.
 GO:0042987; P:amyloid precursor protein catabolic process; IEA:Compara.
 GO:0016044; P:cellular membrane organization; IEA:Compara.
 GO:0006695; P:cholesterol biosynthetic process; ISS:UniProtKB.
 GO:0030539; P:male genitalia development; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
 GO:0008285; P:negative regulation of cell proliferation; IMP:RGD.
 GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; ISS:UniProtKB.
 GO:0031639; P:plasminogen activation; IEA:Compara.
 GO:0008104; P:protein localization; IEA:Compara.
 GO:0007265; P:Ras protein signal transduction; IMP:RGD.
 GO:0009725; P:response to hormone stimulus; IEP:RGD.
 GO:0006979; P:response to oxidative stress; ISS:UniProtKB.
 GO:0043588; P:skin development; ISS:UniProtKB. 
Interpro
 IPR016169; CO_DH_flavot_FAD-bd_sub2.
 IPR016166; FAD-bd_2.
 IPR006094; Oxid_FAD_bind_N. 
Pfam
 PF01565; FAD_binding_4 
SMART
  
PROSITE
 PS51387; FAD_PCMH 
PRINTS