CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010086
UniProt Accession
Genbank Protein ID
 U00089 
Genbank Nucleotide ID
Protein Name
 DNA topoisomerase 4 subunit A 
Protein Synonyms/Alias
 Topoisomerase IV subunit A 
Gene Name
 parC 
Gene Synonyms/Alias
 MPN_123; MP031 
Created Date
 July 27, 2013 
Organism
 Mycoplasma pneumoniae (strain ATCC 29342 / M129) 
NCBI Taxa ID
 272634 
Lysine Modification
Position
Peptide
Type
References
458TAERLIAKPQARNQLacetylation[1]
Reference
 [1] Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium.
 van Noort V, Seebacher J, Bader S, Mohammed S, Vonkova I, Betts MJ, Kühner S, Kumar R, Maier T, O'Flaherty M, Rybin V, Schmeisky A, Yus E, Stülke J, Serrano L, Russell RB, Heck AJ, Bork P, Gavin AC.
 Mol Syst Biol. 2012 Feb 28;8:571. [PMID: 22373819] 
Functional Description
 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule (By similarity). 
Sequence Annotation
 ACT_SITE 122 122 O-(5'-phospho-DNA)-tyrosine intermediate  
Keyword
 Cell membrane; Complete proteome; DNA-binding; Isomerase; Membrane; Reference proteome; Topoisomerase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 789 AA 
Protein Sequence
MEKNKQALLL QAIEDVFAFS FSKYAKYIIQ DRALPDLRDG LKPVQRRILY GMYQMGLKPT 60
SPYKKSARAV GEIMGKYHPH GDASIYDAIV RMSQAWKNNL TTISIHGNNG SIDGDNAAAM 120
RYTEARLSPY GFELLKDIEK QLVPFVNNFD DSEVEPSVLP TLLPNLFING TSGIAAGYAT 180
NIAPHNVGEL LDGLSYRIEN PDCDLKAILK IVKGPDFPTG GLVYFEQELA NIYQTGKGKF 240
VIQAKYETNT AFGQNQIVIT EIPYETVKAN IVKQIEELIS DNKLSALESV IDSSDRSGIR 300
IIINHKDFLS ADKIMAFLFK HTQLQVNFNL NNTVIANRCP VRVGLLAYFD QFLAFAHELI 360
INSAKYDLAL ANKRLEIIKG LIKAVSMIDE IIRLIRRATD KQDAKTKLID KYAFTLNQAE 420
AIVSLRLYQL TNTDIKVLFA EQKELEQTIQ TAERLIAKPQ ARNQLLQAQF FQYKKQFNQP 480
RRAQIVGLIE KQKVQDSDFI EHKEVGLLIS HDGIYFKFEP EQLAKHLVEF KSEQDQLIFG 540
GVVQNSDYFF MVTSLGNIIT VPIYKTLSNT KTKMNELLAK KPILMEDEKL VLAGIVNPDK 600
MEQQLLVLTS QCGMVKRVEL SKVINTKQIK SSCCMALRER DKLVNAFVQT KGEPKLVCLV 660
SSSNSFATFL AEEIPIISNK GIGVKGIKLK AEEKVRFAMP LQDNDALVVI NSDGGVYNFE 720
VVELAVASRM SVGKKLIPKT KTPVSCFAAN KHSEIIGHRG KNGSDLFTLN ELNRLPKSTV 780
SQMRLFKWS 789 
Gene Ontology
 GO:0005694; C:chromosome; IEA:InterPro.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0003918; F:DNA topoisomerase type II (ATP-hydrolyzing) activity; IEA:EC.
 GO:0006265; P:DNA topological change; IEA:InterPro. 
Interpro
 IPR024946; Arg_repress_C-like.
 IPR006691; GyrA/parC_pinwhl.
 IPR002205; Topo_IIA_A/C.
 IPR013758; Topo_IIA_A/C_ab.
 IPR013760; Topo_IIA_like_dom.
 IPR005741; TopoIV_A_Gpos. 
Pfam
 PF03989; DNA_gyraseA_C
 PF00521; DNA_topoisoIV 
SMART
 SM00434; TOP4c 
PROSITE
  
PRINTS