CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042517
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 ATP-binding cassette sub-family A member 2 
Protein Synonyms/Alias
  
Gene Name
 ABCA2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
1376QRMPVSTKPVEDDVDubiquitination[1, 2, 3]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1441 AA 
Protein Sequence
XGRFYFLYGF VWIQDMMERA IIDTFVGHDV VEPGSYVQMF PYPCYTRDDF LFVIEHMMPL 60
CMVISWVYSV AMTIQHIVAE KEHRLKEVMK TMGLNNAVHW VAWFITGFVQ LSISVTALTA 120
ILKYGQVLMH SHVVIIWLFL AVYAVATIMF CFLVSVLYSK AKLASACGGI IYFLSYVPYM 180
YVAIREEVAH DKITAFEKCI ASLMSTTAFG LGSKYFALYE VAGVGIQWHT FSQSPVEGDD 240
FNLLLAVTML MVDAVVYGIL TWYIEAVHPG MYGLPRPWYF PLQKSYWLGS GRTEAWEWSW 300
PWARTPRLSV MEEDQACAME SRRFEETRGM EEEPTHLPLV VCVDKLTKVY KDDKKLALNK 360
LSLNLYENQV VSFLGHNGAG KTTTMSILTG LFPPTSGSAT IYGHDIRTEM DEIRKNLGMC 420
PQHNVLFDRL TVEEHLWFYS RLKSMAQEEI RREMDKMIED LELSNKRHSL VQTLSGGMKR 480
KLSVAIAFVG GSRAIILDEP TAGVDPYARR AIWDLILKYK PGRTILLSTH HMDEADLLGD 540
RIAIISHGKL KCCGSPLFLK GTYGDGYRLT LVKRPAEPGG PQEPGLASSP PGRAPLSSCS 600
ELQVSQFIRK HVASCLLVSD TSTELSYILP SEAAKKGAFE RLFQHLERSL DALHLSSFGL 660
MDTTLEEVFL KVSEEDQSLE NSEADVKESR KDVLPGAEGP ASGEGHAGNL ARCSELTQSQ 720
ASLQSASSVG SARGDEGAGY TDVYGDYRPL FDNPQDPDNV SLQEVEAEAL SRVGQGSRKL 780
DGGWLKVRQF HGLLVKRFHC ARRNSKALFS QILLPAFFVC VAMTVALSVP EIGDLPPLVL 840
SPSQYHNYTQ PRGNFIPYAN EERREYRLRL SPDASPQQLV STFRLPSGVG ATCVLKSPAN 900
GSLGPTLNLS SGESRLLAAR FFDSMCLESF TQGLPLSNFV PPPPSPAPSD SPASPDEDLQ 960
AWNVSLPPTA GPEMWTSAPS LPRLVREPVR CTCSAQGTGF SCPSSVGGHP PQMRVVTGDI 1020
LTDITGHNVS EYLLFTSDRF RLHRYGAITF GNVLKSIPAS FGTRAPPMVR KIAVRRAAQV 1080
FYNNKGYHSM PTYLNSLNNA ILRANLPKSK GNPAAYGITV TNHPMNKTSA SLSLDYLLQG 1140
TDVVIAIFII VAMSFVPASF VVFLVAEKST KAKHLQFVSG CNPIIYWLAN YVWDMLNYLV 1200
PATCCVIILF VFDLPAYTSP TNFPAVLSLF LLYGWSITPI MYPASFWFEV PSSAYVFLIV 1260
INLFIGITAT VATFLLQLFE HDKDLKVVNS YLKSCFLIFP NYNLGHGLME MAYNEYINEY 1320
YAKIGQFDKM KSPFEWDIVT RGLVAMAVEG VVGFLLTIMC QYNFLRRPQR MPVSTKPVED 1380
DVDVASERQR VLRGDADNDM VKIENLTKVG SGHVGWGLGG VGQGQGGGAP AVEVEPGWAG 1440
P 1441 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0016887; F:ATPase activity; IEA:InterPro.
 GO:0006200; P:ATP catabolic process; IEA:GOC. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR026082; ABC_A.
 IPR003439; ABC_transporter-like.
 IPR017871; ABC_transporter_CS.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00005; ABC_tran 
SMART
 SM00382; AAA 
PROSITE
 PS00211; ABC_TRANSPORTER_1
 PS50893; ABC_TRANSPORTER_2 
PRINTS