CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011971
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Glutamate receptor ionotropic, kainate 2 
Protein Synonyms/Alias
 GluK2; Excitatory amino acid receptor 4; EAA4; Glutamate receptor 6; GluR-6; GluR6 
Gene Name
 GRIK2 
Gene Synonyms/Alias
 GLUR6 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
886PQAPVIVKTEEVINMsumoylation[1]
Reference
 [1] SUMOylation regulates kainate-receptor-mediated synaptic transmission.
 Martin S, Nishimune A, Mellor JR, Henley JM.
 Nature. 2007 May 17;447(7142):321-5. [PMID: 17486098] 
Functional Description
 Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. Modulates cell surface expression of NETO2 (By similarity). 
Sequence Annotation
 REGION 516 518 Glutamate binding (By similarity).
 REGION 689 690 Glutamate binding (By similarity).
 BINDING 523 523 Glutamate (By similarity).
 BINDING 738 738 Glutamate (By similarity).
 MOD_RES 846 846 Phosphoserine; by PKC.
 MOD_RES 868 868 Phosphoserine; by PKC.
 CARBOHYD 67 67 N-linked (GlcNAc...) (Potential).
 CARBOHYD 73 73 N-linked (GlcNAc...) (Potential).
 CARBOHYD 275 275 N-linked (GlcNAc...) (Potential).
 CARBOHYD 378 378 N-linked (GlcNAc...) (Potential).
 CARBOHYD 412 412 N-linked (GlcNAc...) (Potential).
 CARBOHYD 423 423 N-linked (GlcNAc...) (Potential).
 CARBOHYD 430 430 N-linked (GlcNAc...) (Potential).
 CARBOHYD 546 546 N-linked (GlcNAc...) (Potential).
 DISULFID 96 347 By similarity.
 CROSSLNK 886 886 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 3D-structure; Alternative splicing; Cell junction; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Ion channel; Ion transport; Isopeptide bond; Ligand-gated ion channel; Membrane; Mental retardation; Phosphoprotein; Polymorphism; Postsynaptic cell membrane; Receptor; Reference proteome; RNA editing; Signal; Synapse; Transmembrane; Transmembrane helix; Transport; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 908 AA 
Protein Sequence
MKIIFPILSN PVFRRTVKLL LCLLWIGYSQ GTTHVLRFGG IFEYVESGPM GAEELAFRFA 60
VNTINRNRTL LPNTTLTYDT QKINLYDSFE ASKKACDQLS LGVAAIFGPS HSSSANAVQS 120
ICNALGVPHI QTRWKHQVSD NKDSFYVSLY PDFSSLSRAI LDLVQFFKWK TVTVVYDDST 180
GLIRLQELIK APSRYNLRLK IRQLPADTKD AKPLLKEMKR GKEFHVIFDC SHEMAAGILK 240
QALAMGMMTE YYHYIFTTLD LFALDVEPYR YSGVNMTGFR ILNTENTQVS SIIEKWSMER 300
LQAPPKPDSG LLDGFMTTDA ALMYDAVHVV SVAVQQFPQM TVSSLQCNRH KPWRFGTRFM 360
SLIKEAHWEG LTGRITFNKT NGLRTDFDLD VISLKEEGLE KIGTWDPASG LNMTESQKGK 420
PANITDSLSN RSLIVTTILE EPYVLFKKSD KPLYGNDRFE GYCIDLLREL STILGFTYEI 480
RLVEDGKYGA QDDANGQWNG MVRELIDHKA DLAVAPLAIT YVREKVIDFS KPFMTLGISI 540
LYRKPNGTNP GVFSFLNPLS PDIWMYILLA YLGVSCVLFV IARFSPYEWY NPHPCNPDSD 600
VVENNFTLLN SFWFGVGALM QQGSELMPKA LSTRIVGGIW WFFTLIIISS YTANLAAFLT 660
VERMESPIDS ADDLAKQTKI EYGAVEDGAT MTFFKKSKIS TYDKMWAFMS SRRQSVLVKS 720
NEEGIQRVLT SDYAFLMEST TIEFVTQRNC NLTQIGGLID SKGYGVGTPM GSPYRDKITI 780
AILQLQEEGK LHMMKEKWWR GNGCPEEESK EASALGVQNI GGIFIVLAAG LVLSVFVAVG 840
EFLYKSKKNA QLEKRSFCSA MVEELRMSLK CQRRLKHKPQ APVIVKTEEV INMHTFNDRR 900
LPGKETMA 908 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0005622; C:intracellular; IEA:Compara.
 GO:0032983; C:kainate selective glutamate receptor complex; IEA:Compara.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
 GO:0042734; C:presynaptic membrane; IEA:Compara.
 GO:0005234; F:extracellular-glutamate-gated ion channel activity; IEA:InterPro.
 GO:0015277; F:kainate selective glutamate receptor activity; IDA:UniProtKB.
 GO:0001662; P:behavioral fear response; IEA:Compara.
 GO:0006874; P:cellular calcium ion homeostasis; IEA:Compara.
 GO:0006886; P:intracellular protein transport; IEA:Compara.
 GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Compara.
 GO:0050806; P:positive regulation of synaptic transmission; IMP:UniProtKB.
 GO:0019228; P:regulation of action potential in neuron; IEA:Compara.
 GO:0060079; P:regulation of excitatory postsynaptic membrane potential; IEA:Compara.
 GO:0060080; P:regulation of inhibitory postsynaptic membrane potential; IEA:Compara.
 GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IEA:Compara.
 GO:0048172; P:regulation of short-term neuronal synaptic plasticity; IMP:UniProtKB.
 GO:0007268; P:synaptic transmission; TAS:Reactome.
 GO:0035249; P:synaptic transmission, glutamatergic; IEA:Compara. 
Interpro
 IPR001828; ANF_lig-bd_rcpt.
 IPR019594; Glu_rcpt_Glu/Gly-bd.
 IPR001320; Iontro_glu_rcpt.
 IPR001508; NMDA_rcpt. 
Pfam
 PF01094; ANF_receptor
 PF00060; Lig_chan
 PF10613; Lig_chan-Glu_bd 
SMART
 SM00918; Lig_chan-Glu_bd
 SM00079; PBPe 
PROSITE
  
PRINTS
 PR00177; NMDARECEPTOR.